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Study to check if an ultrasound test can predict kidney problems and confusion after heart valve surgery

Evaluation of VExUS Score for Predicting Postoperative Acute Kidney Injury and Delirium in Cardiac Surgical Patients Undergoing Valvular Surgeries: A Prospective Observational Cohort Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/03/106184
Enrollment
70
Registered
2026-03-13
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I083- Combined rheumatic disorders of mitral, aortic and tricuspid valves

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

Dr Dhiraj Chopra
Lead Sponsor
Dr Pooja Singh
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18-70 years 2. Either sex 3. Scheduled for valvular surgery under cardiopulmonary bypass, including Aortic valve replacement, Mitral valve replacement/repair with tricuspid valve repair or Double valve replacement

Exclusion criteria

Exclusion criteria: 1. Not willing to participate 2. Emergency surgery 3. Prior cardiac surgery/ Redo surgery 4. Functional hepatic disease 5. Functional renal disease 6. Pre-operative acute kidney injury 7. Severe pre-operative renal dysfunction; eGFR 8. Kidney transplant recipients 9. Patients receiving peri-operative mechanical circulatory support (IABP or ECMO) 10. Pre-operative delirium 11. Any congenital/acquired cerebrovascular/neurological disorder 12. History of psychotic drugs intake 13. Alcohol and substance abuse 14. Pregnancy

Design outcomes

Primary

MeasureTime frame
1.To determine the sensitivity and specificity between VExUS score grades and the incidence and severity of acute kidney injury (AKI) using KDIGO criteria within 48 hours of valvular surgery. 2. To determine the sensitivity and specificity between VExUS scores and the incidence and severity of post-operative delirium, using the CAM-ICU 7 assessment tool within 48 hours of valvular surgery.Timepoint: Till 48 hours after the cardiac surgery—

Secondary

MeasureTime frame
1. To determine the sensitivity, specificity, predictive value of each ultrasound assessment (Hepatic, Portal and Intrarenal veins) of the VExUS score for AKI and delirium. 2. To determine the sensitivity, specificity, predictive value and hazards ratio of NT-pro BNP with postoperative AKI and delirium after valvular surgery. 3. To determine the association of combination model of VExUS score and NT pro-BNP for development of AKI and delirium. 4. To identify the association between key risk factors (age, comorbidities, anaesthesia duration, CPB, cross clamp time, mean CVP value) with AKI and postoperative delirium.Timepoint: Till 48 hours after the cardiac surgery—

Countries

India

Contacts

Public ContactDr Dhiraj Chopra

All India Institute of Medical Sciences Bhopal

pooja.anesth@aiimsbhopal.edu.in9340969292

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026