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A study comparing two medicines (Sugammadex vs. Neostigmine) to see which works better and faster at stopping the effects of a muscle relaxant drug in adults having planned surgery

EFFICACY OF SUGAMMADEX VERSUS NEOSTIGMINE FOR REVERSAL OF ROCURONIUM-INDUCED NEUROMUSCULAR BLOCKADE IN ADULTS UNDERGOING ELECTIVE SURGERY: A RANDOMISED CONTROLLED STUDY - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/03/106125
Enrollment
100
Registered
2026-03-13
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: NA: NA Control Intervention1: Sugammadex group: At the end of surgery, neuromuscular blockade will be reversed using sugammadex 2 mg/kg body weight (2ml vial contains 100mg/ml of drug w

Sponsors

Sir Ganga Ram Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I and II Duration of surgery is less than 2 hours

Exclusion criteria

Exclusion criteria: Patients refusing to participate in the study Patients with known neuromuscular disorders Patients undergoing organ transplant surgery emergency procedures and patients needing intensive care admission in the postoperative period Obese patients with a body mass index BMI greater than 30kg/m2 Renal or hepatic dysfunction Women taking oral contraceptives Pregnant patients Allergy to drugs under study

Design outcomes

Primary

MeasureTime frame
Time required to achieve the quantitative neuromuscular monitoring endpoint (TOFR 0.9) following the administration of the reversal agents under investigationTimepoint: At time of giving reversal agent When TOFR reached 0.9—

Secondary

MeasureTime frame
patients having bronchospasm, tachypnea with respiratory rate greater than 24 per min, SpO2 less than 92 % at room air during the first 60 min after extubation, in the PACU. patients requiring airway support (viz. airway opening manoeuvres, oral or nasal airway insertion, CPAP / BiPAP, endotracheal intubation) during the first 60 min after extubation, in the PACU. patients having heart rate greater than 100/min or less than 60/min, systolic blood pressure plus minus 20% of baseline, diastolic blood pressure plus minus 20% of baseline, and mean blood pressure plus minus 20% of baseline, after administration of reversal agent, continuing to PACU for the first 60 min post-extubation. Timepoint: till 60 mins after extubation—

Countries

India

Contacts

Public ContactThangasiva P

Institute of Anaesthesiology, Pain and Perioperative Medicin

drabhjit@gmail.com9650140022

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026