Study in patients undergoing surgery to see if giving a small initial dose of propofol before the full dose reduces total propofol requirement and blood pressure and heart rate changes during anaesthesia

A comparative study on the total dose requirements and hemodynamic alterations with and without the application of priming principle among patients induced with propofol - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/106098

Enrollment

Registered

2026-03-13

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Propofol priming technique: Patients will receive 20 percent of the calculated induction dose of intravenous Propofol (0.4 mg per kg) as a priming dose. After 30 seconds, the remaining

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I and II Age 18 to 60 years BMI 18.5 to 30 kg per m Scheduled for elective surgery under general anaesthesia Requiring endotracheal intubation Mallampati grade I or II

Exclusion criteria

Exclusion criteria: Patient refusal ASA III or above History of allergy to propofol or its components Anticipated difficult airway Pregnant or lactating women Patients on medications affecting cardiovascular system (beta blockers, calcium channel blockers etc.)

Design outcomes

Primary

Measure	Time frame
To compare the total induction dose of propofol required with and without application of the priming principle To compare hemodynamic parameters (heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure) between both groupsTimepoint: 30 minutes post induction	—

Secondary

Measure	Time frame
To assess the incidence of complications like apnoea, fasciculation, involuntary movements, Pain on injectionTimepoint: At the time of induction of anaesthesia	—

Countries

India

Contacts

Public ContactDr Namrata Shah

B.J. Medical college and Civil hospital Ahmedabad

drnamrata99@yahoo.com9825521519

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026