To compare the effect of the drug magnesium sulphate given as gargling route before surgery versus given in the cuff of endotracheal tube to reduce postoperative sore throat after spine surgeries

Effect of intracuff versus gargle with magnesium sulphate on postoperative sore throat in patients undergoing spine surgery A randomised double blind study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/106077

Enrollment

118

Registered

2026-03-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M539- Dorsopathy, unspecified Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Gargle with dextrose and intracuff administration of magnesium sulphate to reduce postoperative sore throat following spine surgeries: Group I-Gargle with 20 mL of 5 percent Dextrose fo

Eligibility

Inclusion criteria

Inclusion criteria: ASA Physical status 1 and 2 Patients undergoing elective spine surgery under general anesthesia in prone position

Exclusion criteria

Exclusion criteria: Cervical spine surgeries Patients on treatment with Mg, CCBs Patients allergic or contraindicated to MgSO4 Patient with sore throat or active URTI or Bronchial asthma or COPD Patients with anticipated difficult intubation or multiple intubation attempts Duration of Surgery less than 1 hour and greater than 5 hours Patients requiring post operative mechanical ventilation

Design outcomes

Primary

Measure	Time frame
Incidence of POST at 1 h postoperatively in patients undergoing spine surgery under general anesthesia in prone positionTimepoint: 1 hour postoperatively	—

Secondary

Measure	Time frame
1.To compare the incidence of POST at 4,8,12 and 24 hours postoperatively.Timepoint: Incidence of POST at 4,8,12 and 24 hours postoperatively;2.To compare the severity scores of POST by Numerical rating scale at 1, 4,8,12 and 24 hours postoperatively.Timepoint: Severity scores of POST by Numerical rating scale at 1, 4,8,12 and 24 hours postoperatively.;3.To compare the severity scores of cough and hoarseness by Numerical rating scale at 1,4,8,12 and 24 hours postoperatively.Timepoint: Severity scores of cough and hoarseness by Numerical rating scale at 1,4,8,12 and 24 hours postoperatively.;To assess the quality of recovery with QoR 15 score on day 1 and day 7 after surgery telephonically.Timepoint: QoR 15 score on day 1 and day 7 after surgery	—

Measure

Time frame

1.To compare the incidence of POST at 4,8,12 and 24 hours postoperatively.Timepoint: Incidence of POST at 4,8,12 and 24 hours postoperatively;2.To compare the severity scores of POST by Numerical rating scale at 1, 4,8,12 and 24 hours postoperatively.Timepoint: Severity scores of POST by Numerical rating scale at 1, 4,8,12 and 24 hours postoperatively.;3.To compare the severity scores of cough and hoarseness by Numerical rating scale at 1,4,8,12 and 24 hours postoperatively.Timepoint: Severity scores of cough and hoarseness by Numerical rating scale at 1,4,8,12 and 24 hours postoperatively.;To assess the quality of recovery with QoR 15 score on day 1 and day 7 after surgery telephonically.Timepoint: QoR 15 score on day 1 and day 7 after surgery

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Countries

India

Contacts

Public ContactDr S R A N Bhushanam Padala

AIIMS Bhopal

Padala72@gmail.com7893562302

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026