Health Condition 1: T758- Other specified effects of external causes
Conditions
Interventions
Intervention1: 1.Sequential Mindful Breathing (Ojas Breath)
2.Standardized Tobacco Cessation Counseling
3. Curcumin Supplementation: 1. Sequential Mindful Breathing (Ojas Breath) Protocol
This stru
Sponsors
DrPKMeena priya
Eligibility
Inclusion criteria
Inclusion criteria: Participants meeting all of the following criteria will be included: Adults aged 18 60 years. Clinically diagnosed cases of oral leukoplakia based on standard clinical criteria. Presence of measurable lesion(s) suitable for dimensional assessment. Willingness to undergo curcumin supplementation and tobacco cessation counseling. Willingness to learn and practice Sequential Mindful Breathing (Ojas Breath) (for study group participants). Ability to provide written informed consent.
Exclusion criteria
Exclusion criteria: Participants meeting any of the following criteria will be excluded: Use of antioxidant supplements or herbal antioxidant therapy within the past 1 month. Presence of systemic diseases known to significantly influence oxidative stress or uric acid metabolism (e.g., uncontrolled diabetes mellitus, chronic kidney disease, gout). Current use of medications affecting uric acid levels (e.g., allopurinol, febuxostat, thiazide diuretics). History of malignancy or clinically suspected malignant transformation of the lesion. Pregnancy or lactation. Ongoing participation in another clinical trial. Inability to comply with the 8-week follow-up schedule. Physical or cognitive limitations that prevent proper performance of the breathing protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean change in capillary blood uric acid level from baseline to 8 weeks, compared between the study and control groups.Timepoint: Mean change in capillary blood uric acid level from baseline to 8 weeks, compared between the study and control groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Mean change in lesion area from baseline to Week 8. 2.Proportion of participants achieving CR or PR at Week 8.Timepoint: Clinical lesion measurements will be recorded at baseline, Week 4, and Week 8, with final response classification performed at Week 8. | — |
Countries
India
Contacts
Public ContactDrPKMeena priya
JKKN Dental College
Outcome results
None listed