A Study to see whether adding probiotics to regular skin treatment improves Acne in young adults

To Compare the Efficacy and Safety of Probiotics as an Add on Therapy Vs Topical Therapy alone in patients of Acne Vulgaris A Randomized Controlled Study - NIL

Status

Recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105999

Enrollment

150

Registered

2026-03-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L700- Acne vulgaris

Interventions

Intervention1: Topical Clindamycin phosphate gel Topical Benzoyl Peroxide gel Topical Adapalene gel Vs Oral Probiotic Lactobacillus rhamnosus capsule: Topical therapy Vs Topical therapy plus Oral Prob

Eligibility

Inclusion criteria

Inclusion criteria: Age 18 to 35 years Newly Diagnosed cases with Grade One and Grade Two Acne vulgaris

Exclusion criteria

Exclusion criteria: Severe nodulocystic acne requiring systemic isotretinoin Grade 3 Acne vulgaris or Pustular acne requiring oral antibiotics Antibiotic or Probiotic Therapy within the last 4 weeks Severely immunocompromised patients Pregnancy or lactation Known allergy to study products

Design outcomes

Primary

Measure	Time frame
Improvement in Global Acne Grading System score between topical therapy and oral probioticTimepoint: 18 months	—

Secondary

Measure	Time frame
Improvement in Dermatology Life Quality Index Improvement in Serum Testosterone levels Number of Adverse drug reactionsTimepoint: 18 months	—

Countries

India

Contacts

Public ContactRajat Gupta

Jawaharlal Nehru Medical College Aligarh Muslim University Aligarh

dr.farhan.k@gmail.com9759468300

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026