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Graded Early Mobilization on Non-Invasive vs Invasive Mechanical Ventilation in COPD Patients with Acute Respiratory Failure

Evaluation of Comparative Efficacy of Graded Early Mobilization with Conventional Physiotherapy on Non-Invasive vs Invasive Mechanical Ventilation in COPD Patients with Acute Respiratory Failure: A Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/03/105982
Enrollment
96
Registered
2026-03-12
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J80- Acute respiratory distress syndrome

Interventions

Intervention1: Graded Early Mobilization with Conventional Physiotherapy on Non- Invasive Mechanically Ventilation: Total Duration for each patient is 5 days. Total duration of study 1 years For Non-

Sponsors

Ravi Nair Physiotherapy College, Wardha
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Subject will be included only when diagnosed with COPD with Acute Respiratory Failure by the Intensivist or Respiratory Medicine Specialist, by the criteria of partial pressure of arterial oxygen (PaO2) less than 60 mmHg from ABG analysis report or a pulse oximetry reading (SpO2) less than 90%. (Naughton, 2020) 2. Subject will be included when admitted to the ICU and will be on non-invasive or invasive mechanical ventilation within 24 hours with standard PEEP of 5 2 cm H2O. with CPAP mode. (Grieco, 2021) 3. Independent in functional activities before admission to the hospital.

Exclusion criteria

Exclusion criteria: 1. Subject will be excluded if not diagnosed with COPD with ARF. 2. Subject will be excluded if they have a history of undergoing any surgery, like thoracic, cardiac, abdominal, or fractures. 3. Subject will be excluded if they have any condition that restricts mobility. 4. Subject will be excluded if they have ulcers or open wounds. 5. Subject will be excluded if they have been medically diagnosed with Cancer or metastasis or history of Chemotherapy or radiotherapy within the previous 6 months. 6. Subject will be excluded if they have already been medically diagnosed with neurological deficits or neuromuscular disease 7. Subject will be excluded if they have invasive femoral arterial lines or are on immunosuppression therapy.

Design outcomes

Primary

MeasureTime frame
PaO2 - ABG InvestigationTimepoint: Base Line & on the 5th day

Secondary

MeasureTime frame
SpO2 Pulse OximeterTimepoint: Base Line & on the 5th day;Fatigue - Fatigue Assessment Scale (FAS)Timepoint: Base Line & on the 5th day;Perme Intensive Care Unit Mobility ScoreTimepoint: Base Line & on the 5th day;Respiratory Distress Observation Scale (RDOS)Timepoint: Base Line & on the 5th day

Countries

India

Contacts

Public ContactDr Abhijit D Diwate

Ravi Nair Physiotherapy College, Wardha

irshad.qureshi@dmiher.edu.in9406010010

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026