ALLOPURINOL RESCUE- DOES THE USAGE OF ALLOPURINOL DRUG HELP IN RECOVERY OF BURN INJURIES?

Allopurinol Rescue- The Unexplored Role Of Xanthine Oxidase Inhibitors On Prognosis Of Major Burn Injuries - Nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105903

Enrollment

Registered

2026-03-11

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: T313- Burns involving 30-39% of body surface Health Condition 2: T314- Burns involving 40-49% of body surface Health Condition 3: T273- Burn of respiratory tract, part unspecified

Interventions

Intervention1: Oral allopurinol + standard treatment protocol: 300mg of oral Allopurinol per day for the first three days after admission Control Intervention1: Standard treatment protocol only: Stan

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with 30-50% TBSA burns and inhalational injury 2. Presentation less than 12 hours of burn injury 3. Patients willing to give consent for participation in the study

Exclusion criteria

Exclusion criteria: 1. Patients with pre-existing renal dysfunction 2. Patients with ongoing treatment with XO inhibitors at the time of presentation 3. Known hypersensitivity to Allopurinol

Design outcomes

Primary

Measure	Time frame
Serial Xanthine oxidase and LPO levelsTimepoint: at presentation, at day 3	—

Secondary

Measure	Time frame
-Duration of hospital stay -MortalityTimepoint: At day 0 day 3 day 7 day 14 & weekly thereafter	—

Countries

India

Contacts

Public ContactChandrashekar M S

Mysore medical College and research institute

mscchandrashekar@gmail.com9916377778

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026