Precooled Lignocaine and Ibuprofen as Preanesthetic Medication on Success rate of Pulpal Anesthesia: A Randomized Controlled Trial

Effect of Precooled Lignocaine in Combination with Ibuprofen as Preanesthetic Medication on Success rate of Pulpal Anesthesia in Mandibular Molars with Symptomatic Irreversible Pulpitis: a Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105902

Enrollment

Registered

2026-03-11

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: LIGNOCAINE WITH IBUPRUFEN: Pre-anesthetic medication with ibuprufen one hour prior to treatment and administration of lignocaine during the procedure Intervention2: Precooled lignocaine

Eligibility

Inclusion criteria

Inclusion criteria: 1. Asian healthy (ASA I) subjects of either gender between 18 and 50 years of age. 2. Patients diagnosed with symptomatic irreversible pulpitis in mandibular molars

Exclusion criteria

Exclusion criteria: Patients on medication with analgesics for dental pain within last 24 hours Patients allergic to lignocaine and adrenaline Patients allergic to ibuprofen Patients with peptic ulcers, or any underlying Gastrointestinal tract conditions/diseases. Patients with renal disorders. Patients with poor oral hygiene and periodontal disease Patients with chronic pain syndromes and neuropathic disorders Patients with thrombocytopenia and related conditions Patients with autoimmune disease Pregnant patients

Design outcomes

Primary

Measure	Time frame
To investigate the effectiveness of precooled lignocaine in combination with ibuprofen as pre-anaesthetic medication on success rate of pulpal anaesthesia in mandibular molars with symptomatic irreversible pulpitis. Timepoint: pain recorded during endodontic treatment approximately lasting for 45mins to 1 hour	—

Secondary

Measure	Time frame
1. To evaluate the success rate of pulpal anaesthesia with precooled anaesthesia in mandibular molars with symptomatic irreversible pulpitis 2. To evaluate the success rate of pulpal anaesthesia with Pre-anaesthetic medication in combination with precooled anaesthesia in mandibular molars with symptomatic irreversible pulpitis. 3. To compare the above Timepoint: pain recorded during endodontic treatment approximately lasting for 45mins to 1 hour	—

Measure

Time frame

1. To evaluate the success rate of pulpal anaesthesia with precooled anaesthesia in mandibular molars with symptomatic irreversible pulpitis 2. To evaluate the success rate of pulpal anaesthesia with Pre-anaesthetic medication in combination with precooled anaesthesia in mandibular molars with symptomatic irreversible pulpitis. 3. To compare the above Timepoint: pain recorded during endodontic treatment approximately lasting for 45mins to 1 hour

—

Countries

India

Contacts

Public ContactDr Sidhartha Sharma

sid.aiims@gmail.com9582542655

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026