Health Condition 1: I977- Intraoperative cardiac functionaldisturbances Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: IVABRADINE: TAB. IVABRADINE 5MG 1 hour prior to induction of surgery
Control Intervention1: GABAPENTIN: TAB. GABAPENTIN 800MG 1 hour prior to induction of surgery
Control Intervention2:
Sponsors
AKHILESH MUKERJI
Eligibility
Inclusion criteria
Inclusion criteria: 1. ASA grade I or II fit patients. 2. Patients aged between 18 years and 60 years of age belonging to either sex 3. Patients undergoing surgeries under general anaesthesia requiring intubation. 4. Haemodynamically stable patients with all routine investigations within normal limits and without any comorbidities. 5. Written informed consent from the concerned patient.
Exclusion criteria
Exclusion criteria: 1. Patients who have history of allergy to the drug being used for the study. 2. Patients who are not willing to participate in the study. 3. Patients will HR less than 60 and Heart Block conditions. 4. Patients on medications that affect the heart rate or blood pressure, pregnant patients. 5. Patients with ASA grade III and above physical status. 6. Patients who are aged less than 18 years and more than 60 years of age. 7. Patients who are posted for emergency procedures. 8. Patients who have psychiatric, neurological, cardiovascular disease, difficult airway or impairment of hepatic or renal function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the effects of oral Ivabradine and Gabapentin on haemodynamic response such as Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP) during laryngoscopy and intubation.Timepoint: Baseline (before administration of study drug), preoperatively, 0 minute (intubation) 1 minute after intubation, 3rd minute after intubation, 5th minute after intubation, 8th minute after intubation, 10th minute after intubation, 30 minutes, 60 minutes 90 minutes 120 minutes 2 hours post operatively, 6 hours post operatively | — |
Secondary
| Measure | Time frame |
|---|---|
| Determine which drug more effectively attenuates the haemodynamic responseTimepoint: Baseline (before administration of study drug), preoperatively, at induction, at intubation, 1 minute after intubation, 3rd minute after intubation, 5th minute after intubation, 8th minute after intubation, 10th minute after intubation, 30 minutes, 60 minutes 90 minutes 120 minutes 2 hours post operatively, 6 hours post operatively;To evaluate the incidence of adverse events & sedation related to the study drug.Timepoint: Baseline (before administration of study drug), preoperatively, at induction, at intubation, 1 minute after intubation, 3rd minute after intubation, 5th minute after intubation, 8th minute after intubation, 10th minute after intubation, 30 minutes, 60 minutes 90 minutes 120 minutes 2 hours post operatively, 6 hours post operatively | — |
Countries
India
Contacts
Public ContactDr Bhavini Bhushan Shah
Department of Anaesthesiology, Dr. D.Y.Patil Medical College, Hospital and Research Centre
Outcome results
None listed