Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Intravenous injection of Dexmedetomidine 0.5mcg/kg : Intravenous injection of Dexmedetomidine 0.5mcg/kg over 10 minutes prior to induction of anaesthesia to the patient and to monitor
Sponsors
Smt.Bhikiben Kanjibhai Shah Medical Institute and Research Centre
Eligibility
Inclusion criteria
Inclusion criteria: Patients willing to sign informed consent. Male or female patients between ages of 18 to 60 years. Patients belonging to American Society of Anaesthesiologists (ASA) physical status I and II. Patients posted for elective surgeries requiring endotracheal intubation under general anaesthesia. Patient having mouth opening more than 3cm Patient with Malampatti grade 1 and 2.
Exclusion criteria
Exclusion criteria: Patients unwilling to participate in the study. Patients belonging to ASA status 3 and 4 Patients having contraindication to endotracheal intubation/general anaesthesia. Patient having mouth opening less than 3cm. Patient with Mallampati grade 3 and 4. Body mass index more than 30 kg.m2. patients taking anxiolytics, sedatives, antipsychotic, or antiepileptic drugs. Patients with history of muscular disorder, myositis or any local infection. Patients with cardiovascular diseases, arrhythmias, heart blocks, or taking beta blockers. Patients with cerebrovascular, hepatic and renal diseases. Psychiatric patients. Patients with history of allergy to an alpha 2 adrenergic agonist and synthetic opioids. Pregnancy and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the effect of single pre operative dose of Dexmedetomidine and Clonidine on haemodynamic response to endotracheal intubation under general anaesthesia.Timepoint: To compare the effect of single pre operative dose of Dexmedetomidine and Clonidine on haemodynamic response to endotracheal intubation under general anaesthesia (Baseline parameters before administration of the study drug, after 5 minutes during the administration of the study drug, just after administration of the study drug, after induction of anaesthesia, after intubation, and at 1,3,5,10,15 minutes post intubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient haemodynamic parameters during extubation. Post operative Sedation effectTimepoint: Just after extubation and 15,30,60 minutes post extubation. | — |
Countries
India
Contacts
Public ContactDr Nilesh Shah
Smt.Bhikiben Kanjibhai Shah Medical Institute and Research Centre
Outcome results
None listed