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A study to evaluate how Antibiotics Are Started and Fine-Tuned in ICU Infections

A Prospective Observational Study on Antibiotic De-escalation Practices and Outcomes in ICU Patients with Suspected or Confirmed Infections - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/03/105773
Enrollment
500
Registered
2026-03-10
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nil: Nil Control Intervention1: Nil: NA

Sponsors

Tata Memorial Centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adults more than 18 years admitted to ICU 2. Broad spectrum antibiotic use in first 48 hours of ICU admission 3. Expected ICU stay more than or equal to 48 hours.

Exclusion criteria

Exclusion criteria: Advanced malignancy with Best supportive care

Design outcomes

Primary

MeasureTime frame
Rate of (Antibiotic de-escalation) ADE within the cohortTimepoint: Day 2 to day 28 of starting antibiotic—

Secondary

MeasureTime frame
1. Rate of early discontinuation of all antimicrobial therapy within the cohort 2. Duration of antibiotic therapy 3. Incidence of de-escalation in different infection types 4. Reason for no De-escalation 5. ICU and hospital length of stay (LOS). 6. ICU mortality. 7. Positive test for C. difficile within 28 days of initial antimicrobial Timepoint: Day 2 to day 28 of starting antibiotic—

Countries

India

Contacts

Public ContactAjai John Mathew

ACTREC, Tata Memorial Centre

amolkothekar@yahoo.com9769633568

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026