Comparing the Efficacy of Fractional Co2 Laser with Topical Tranexamic acid 5 Percent gel versus with Topical Isobioniacinamide Cysteamine Complex cream in Treatment of Melasma

A STUDY OF EFFICACY AND SAFETY OF FRACTIONAL CO2 LASER WITH TOPICAL TRANEXAMIC ACID 5 PERCENT GEL VERSUS FRACTIONAL CO2 LASER WITH TOPICAL ISOBIONIACINAMIDE CYSTEAMINE COMPLEX CREAM IN THE TREATMENT OF MELASMA- A RANDOMIZED CONTROLLED TRIAL - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105764

Enrollment

Registered

2026-03-10

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L811- Chloasma

Interventions

Intervention1: Fractional Co2 Laser with Topical Tranexaic Acid 5% Gel: patient will be advised to review every 4 weeks and similar sessions will be carried out up to 12 weeks accounting for a total o

Eligibility

Inclusion criteria

Inclusion criteria: Female patient aged 20 to 50 years old with melasma

Exclusion criteria

Exclusion criteria: Consumption of antioxidants in last 3 months Use of isotretinoin in past 6 months Active inflammatory acne lesions Drugs causing photosensitivity and hyperpigmentation as epileptic drugs Antimalaria and tetracycline Pregnancy Patients who have undergone treatment recently with other modalities in past 3 months.

Design outcomes

Primary

Measure	Time frame
1.Measurement of efficacy of modalities on the basis of quartile grading score 2.Modified Melasma Area and Severity Index Score 3.Patient satisfaction using Likert Satisfaction ScaleTimepoint: at baseline every 4 weeks at end of 16 weeks	—

Secondary

Measure	Time frame
side effects of topical Tranexamic 5% gel and topical Isobioniacinamide cysteamine complex in treatment of melasmaTimepoint: at baseline every 4 weeks at end of 16 weeks	—

Countries

India

Contacts

Public ContactDr Rajashekar TS

Sri Devaraj Urs Medical College, Tamaka, Kolar

rajashekardermat@sduaher.ac.in9448316136

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026