Health Condition 1: O021- Missed abortion Health Condition 2: O029- Abnormal product of conception, unspecified
Conditions
Interventions
Intervention1: T.LETROZOLE + T.MISOPROSTOL: T.LETROZOLE 10mg orally once daily from Day 1 to Day 3 followed by on Day-4- Misoprostol 800 mcg sublingually, single dose. (T.Letrozole 10mg will be given
Sponsors
SOUNDHARYA V
Eligibility
Inclusion criteria
Inclusion criteria: Women age 18 yrs and above. Confirmed intrauterine pregnancy upto 9 wks /63 days (based on Ultasound findings). Indications for Termination as per MTP Act . Hemoglobin levels greater than 10g/dl. Willing to participate and provide written and informed consent.
Exclusion criteria
Exclusion criteria: Hypersensitivity to Misoprostol/ Letrozole. Multiple pregnancy. Uterine anomalies. Bronchial asthma. Steroid hormone dependant cancer. Systemic diseases. Coagulopathies/Thromboembolism. Suspected ectopic or Molar pregnancy. Porphyria. Severe or recurrent Liver disease or Pruritis of Pregnancy. Breast feeding. Acute illness of any nature.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare induction abortion interval and rate of complete abortion without the need of surgical intervention between study (LETROZOLE+MISOPROSTOL) and control groups (MIFEPRISTONE+MISOPROSTOL) . Timepoint: Baseline,Day-3,Day-4,Day-5,Day-6 | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess total duration of vaginal bleeding during abortion in both the groups & to make comparison between study & control groups. To assess side effects & complications in both the groups. To evaluate patient satisfaction & tolerability of the regimen in both the groups .(Graded as Satisfactory/Unsatisfactory) Timepoint: Baseline,Day-3,Day-4,Day-5,Day-6 | — |
Countries
India
Contacts
Public ContactSOUNDHARYA V
GOVERNMENT RAJAJI HOSPITAL , MADURAI
Outcome results
None listed