A study to compare a natural herbal medicine (chicory leaf extract) and chlorhexidine gel in improving gum health in patients with chronic gum disease

A clinical, radiographical and microbiological study for evaluating and comparing natural chicory leaf extract with synthetic chlorhexidine in the management of stage 2 grade B chronic periodontitis as a local drug delivery agent: a split-mouth randomized controlled clinical trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105707

Enrollment

Registered

2026-03-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Test Group (Group A): Chicory Leaf Extract Local Drug Delivery: Patients diagnosed with Stage 2 Grade B chronic periodontitis will undergo full mouth scaling and root planing (SRP). Aft

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy individuals Patients diagnosed with Stage 2 Grade B chronic periodontitis Presence of localized bilateral or contralateral periodontal pockets with probing pocket depth (PPD) of 5 7 mm Presence of horizontal alveolar bone loss associated with selected sites Patients willing to participate and able to provide written informed consent

Exclusion criteria

Exclusion criteria: Patients unwilling to participate in the study Presence of any systemic disease or condition that may affect periodontal healing History of antibiotic therapy within the past 6 months Patients who have received periodontal treatment in the past 6 months Patients with known allergy or hypersensitivity to chicory leaf extract or chlorhexidine gel Smokers or tobacco users in any form Pregnant or lactating women Patients with poor oral hygiene compliance

Design outcomes

Primary

Measure	Time frame
Reduction in Probing Pocket Depth (PPD) Timepoint: Baseline,1 month,3 months and 6 months	—

Secondary

Measure	Time frame
Gain in Clinical Attachment Level (CAL)Timepoint: Baseline,1 month,3 months and 6 months ;Reduction in Gingival Index (GI)Timepoint: Baseline,1 month,3 months and 6 months ;Reduction in Plaque Index (PI)Timepoint: Baseline,1 month,3 months and 6 months ;Reduction in subgingival microbial load Timepoint: Baseline and 6 months;Radiographic improvement in alveolar bone levelsTimepoint: Baseline and 6 months;Assessment of patient tolerance and adverse effectsTimepoint: Throughout the study period	—

Measure

Time frame

Gain in Clinical Attachment Level (CAL)Timepoint: Baseline,1 month,3 months and 6 months ;Reduction in Gingival Index (GI)Timepoint: Baseline,1 month,3 months and 6 months ;Reduction in Plaque Index (PI)Timepoint: Baseline,1 month,3 months and 6 months ;Reduction in subgingival microbial load Timepoint: Baseline and 6 months;Radiographic improvement in alveolar bone levelsTimepoint: Baseline and 6 months;Assessment of patient tolerance and adverse effectsTimepoint: Throughout the study period

—

Countries

India

Contacts

Public ContactDr James Samuel

Goa Dental College And Hospital

jamessamueldental@gmail.com9822151608

Outcome results