Comparative Study of Gingival Depigmentation Using Injectable Glutathione, Vitamin C and Tranexamic Acid with and without Low-Level Laser Therapy

Comparative Study of Gingival Depigmentation Using Injectable Glutathione, Vitamin C and Tranexamic Acid with and without Low-Level Laser Therapy: Randomized Controlled Clinical Trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105695

Enrollment

Registered

2026-03-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: test group B: 1. Written informed consent will be obtained 2. Clinical evaluation and baseline pigmentation scoring will be done using Dummet s Gingival Pigmentation Index. 3. Preparati

thrice for three weeks consecutively. 7. Postoperative instructions will be given 8. Follow-up at one, three and six months will be done.

Eligibility

Inclusion criteria

Inclusion criteria: INCLUSION CRITERIA 1) Systemically healthy patients 2) Presence of gingival hyperpigmentation in maxillary and/ or mandibular sextants 3) Age 18 40 years 4) High esthetic concern

Exclusion criteria

Exclusion criteria: EXCLUSION CRITERIA 1) Smokers 2) Pregnant or lactating women 3) Patients with systemic diseases affecting pigmentation 4) History of previous depigmentation treatment

Design outcomes

Primary

Measure	Time frame
Dummet s Gupta Gingival Pigmentation Index (1945) Timepoint: BASELINE, one month, three months and six months	—

Secondary

Measure	Time frame
healing index , VAS pain scoreTimepoint: baseline , one month, three months and six months	—

Countries

India

Contacts

Public ContactDR MANALI SHASHIKANT WAGHMARE

VYWS dental college and hospital

simpar74@gmail.com9977132697

Outcome results