Study of Ketamine and Propofol Combination in Modified Electroconvulsive Therapy

Comparison of different amalgamation of Propofol and Ketamine (ketofol) for Modified Electroconvulsive Therapy -Prospective randomized double blind study - Nil

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105613

Enrollment

Registered

2026-03-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F01-F99- Mental, Behavioral and Neurodevelopmental disorders

Interventions

Intervention1: Group KP1 contain Mixture of Ketamin(10mg/ml) and Propofol (10mg/ml) in ratio of 1:1: In group KP1 will recieve ketofol (dose of 0.5-1mg/kg) via intravenous route in ratio of 1:1 till

Eligibility

Inclusion criteria

Inclusion criteria: 1)adult(male/female) of age from 18 years to 50 years 2) ASA grade 1 or 2 patients schedule for modified electroconvulsive therapy

Exclusion criteria

Exclusion criteria: 1-Pateint with history of diabetes,hypertension, glaucoma and end organ damage 2-History of allergy to studied drug 3-Pregnant or lactating women 4-Presence of foreign body such as pacemaker,intracranial electrode or clips 5-Pateint with feature of raised intracranial pressure

Design outcomes

Primary

Measure	Time frame
Comparison of different combinations of Propofol and Ketamine (ketofol)on seizure quality in terms of seizure durationTimepoint: No such time points for seizure duration (Seizure duration will be taken form shock administration to cessation of tonic clonic moter activity in the isolated limb )	—

Secondary

Measure	Time frame
To evaluate recovery time, hemodynamic parameters and side effects including agitation, shivering, vomiting and headacheTimepoint: Recovery time will be measured from the end of seizure to onset of spontaneous respiration and regaining consciousness Hemodynamic parameters ( SPO2,HR,SBP,DBP,MAP) will be assessed baseline (PRE-ECT), POST-ECT at 1 min,3 min,5 minand 10 min Agitation score will be taken after 10 min POST-ECT Shivering, Vomiting and Headache will be assessed in form of present or absent post ECT	—

Measure

Time frame

To evaluate recovery time, hemodynamic parameters and side effects including agitation, shivering, vomiting and headacheTimepoint: Recovery time will be measured from the end of seizure to onset of spontaneous respiration and regaining consciousness Hemodynamic parameters ( SPO2,HR,SBP,DBP,MAP) will be assessed baseline (PRE-ECT), POST-ECT at 1 min,3 min,5 minand 10 min Agitation score will be taken after 10 min POST-ECT Shivering, Vomiting and Headache will be assessed in form of present or absent post ECT

—

Countries

India

Contacts

Public ContactDr Satish Verma

Institute of Medical Sciences Banaras Hindu University

dryashacin1999@gmail.com9918424416

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026