A study of Accelerated Intermittent Theta Burst Stimulation (aiTBS) for Negative Symptoms in patients with Schizophrenia

Efficacy and Safety of Accelerated Intermittent Theta Burst Stimulation (aiTBS) for Negative Symptoms of Schizophrenia: A Randomised Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105595

Enrollment

Registered

2026-03-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F20- Schizophrenia

Interventions

Intervention1: Accelerated iTBS: Active intervention includes accelerated intermittent theta burst stimulation (aiTBS) over the left dorsolateral prefrontal cortex (DLPFC),1800 pulses per session over

Eligibility

Inclusion criteria

Inclusion criteria: 1. Chronic schizophrenia patients with a duration of illness of more than 2 years 2. PANSS Negative symptom score more than 15 3. Calgary depression scale for schizophrenia score less than 7 4. On stable doses of antipsychotic medications

Exclusion criteria

Exclusion criteria: 1. Neurological disorders, substance dependence (except tobacco) 2. Contraindications for RTMS (pacemakers, metallic implants in brain, head trauma)

Design outcomes

Primary

Measure	Time frame
Change in PANSS Negative symptom scoreTimepoint: At Baseline, end of 5 days, 4 weeks, and 8 weeks	—

Secondary

Measure	Time frame
1. Change in severity of illness (CGI score) 2. To understand the neurophysiological correlates of response as measured by FNIRS-oxy haemoglobin changes over DLPFC Timepoint: Baseline and 8 weeks	—

Countries

India

Contacts

Public ContactDr Godi Sangha Mitra

AIIMS Mangalagiri

mitratriam@gmail.com09492414295

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026