Health Condition 1: K658- Other peritonitis
Conditions
Interventions
Intervention1: N-ACETYL CYSTEINE DOSING IN THE PERIOPERATIVE PERIOD: Two doses of N-Acetyl cysteine will be given in the peri-operative period.
First dose (600mg) after induction of Anaesthesia and se
Sponsors
AIIMS DELHI
Eligibility
Inclusion criteria
Inclusion criteria: Age more than 18 years Confirmed perforation peritonitis requiring laparotomy Informed consent obtained from the patient or legally accepted representative
Exclusion criteria
Exclusion criteria: NAC hypersensitivity Severe Asthma with prior NAC induced bronchospasm Pregnancy/Lactation CKD patient on hemodialysis End stage liver failure Participation in another interventional trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of serum CRP on POD-1 and POD-3 following index laparotomy between the two groupsTimepoint: Post operative day 1 and post operative day 3 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Clavein dindo classification more than grade 3 within 30 days following surgery between the two groups 2) Requirement of new RRT between the two groups within thirty days in the post operative period 3)Length of ICU stay between the two groups 4)Ventilator free days 5)30 day mortality between the two groupsTimepoint: Patients would be followed for 30 days in the post operative period | — |
Countries
India
Contacts
Public ContactDrSai Pavan Ganji
AIIMS DELHI
Outcome results
None listed