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To assess the effect of adding sugar water to numbing medicine in nerve injections for reducing pain among patients with face pain

Assessing the Efficacy of Addition of 5 percent Dextrose to 0.5 percent Lignocaine for Perineural Injection in Improving Pain and Quality of Life among Patients with Trigeminal Neuralgia A Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/03/105577
Enrollment
44
Registered
2026-03-06
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G500- Trigeminal neuralgia

Interventions

Intervention1: dextrose with lignocaine in perineural injection: multiple perineural injections will be given along the distribution of the affected branches of trigeminal nerve with 5 percent dextros

Sponsors

All India Institute of Medical Sciences (AIIMS), New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Diagnosed patients of Trigeminal Neuralgia in one or more divisions of trigeminal nerve 2. Pain persisting with standard pharmacological therapy 3. Able to give informed consent and comply for follow up

Exclusion criteria

Exclusion criteria: 1. Trigeminal neuralgia due to neurovascular compression, tumor, multiple sclerosis, prior microvascular decompression within 6 months, or structural lesions requiring other interventions 2. Coagulopathy, 3. Active infection at injection sites, 4. Uncontrolled diabetes 5. Pregnancy or breastfeeding. 6. Prior perineural injections for Trigeminal neuralgia. 7. Allergy to injection components. 8. Severe psychiatric illness that would limit compliance.

Design outcomes

Primary

MeasureTime frame
1. Numeric Rating Scale (NRS) at 2 weeks after the procedure 2. Change in health-related quality of life assessed using EuroQoL Dimension 5 - 5 Levels (EQ-5D-5L) questionnaire at 2 weeks after the procedure Timepoint: 1. Numeric Rating Scale (NRS) at 2 weeks after the procedure 2. Change in health-related quality of life assessed using EuroQoL Dimension 5 - 5 Levels (EQ-5D-5L) questionnaire at 2 weeks after the procedure—

Secondary

MeasureTime frame
1. Numeric Rating Scale (NRS) at 30 minutes and end of first week after the procedure 2. Number of rescue analgesic (Tramadol 37.5 mg and Acetaminophen 325 mg combination) consumed over 2 weeks 3. Change is the dosage of oral Carbamazepine over 2 weeks 4. Safety and tolerability - adverse events related to injections will be recorded Timepoint: 1. At 30 minutes after the procedure 2. At end of 1 week after the procedure—

Countries

India

Contacts

Public ContactDr Jyotsna Punj

All India Institute of Medical Sciences (AIIMS), New Delhi

jyotsna_punj@yahoo.com9810191116

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026