Comparison of healing and pain after root canal treatment using different cleaning techniques with and without cold irrigation.

Comparative evaluation of two different endodontic instrumentation kinematics and cryotherapy on post endodontic pain and periapical healing in teeth with asymptomatic apical periodontitis - A double blind, prospective randomized clinical trial. - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105569

Enrollment

Registered

2026-03-06

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K045- Chronic apical periodontitis

Interventions

Intervention1: Rotary instrumentation kinematics with or without cryotherapy: : Biomechanical preparation of root canals with rotary file system. This group will be further divided into 2 subgroups of

Eligibility

Inclusion criteria

Inclusion criteria: 1. Systemically healthy (ASA (American Society of Anesthesiologists)-I,II )(22) participants 18 years of age with diagnosis of pulp necrosis and AAP in single rooted lower anteriors and premolars Tooth will be diagnosed as AAP if it shows no clinical symptoms (no pain on percussion or palpation). 2. Radiographic evidence of periapical pathology with PAI score between 2 5

Exclusion criteria

Exclusion criteria: The patients with the following clinical and radiographic features will be excluded from the study: Clinical features: 1. Teeth with previous history of root canal treatment. 2. Teeth requiring severe prosthetic rehabilitation. 3. Pregnant or nursing mothers. 4. Periodontally compromised teeth. 5. Analgesic consumption for at least 12hrs before the visit. Radiographic features: 1. Immature/ Open apex 2. Non-patent apical foramen 3. Root resorption 4. External resorption 5. Calcified pulp canals

Design outcomes

Primary

Measure	Time frame
Pain using NRS-11 scaleTimepoint: Pain using NRS-11 scale	—

Secondary

Measure	Time frame
Periapical IndexTimepoint: 6 months	—

Countries

India

Contacts

Public ContactDr Neena Marya Louis

All India Institute Of Medical Sciences

drganesh11@aiimsnagpur.edu.in9545516096

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026