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Local delivery of blood derived proteins into the gums after deep cleaning to improve gum diseases.

Evaluation Of The Adjunctive Use Of Albuminated Platelet Rich Fibrin (Alb-PRF) Versus Injectable Platelet Rich Fibrin (i-PRF) In Non-Surgical Periodontal Therapy: A Split-Mouth Randomized Clinical Trial - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/03/105554
Enrollment
21
Registered
2026-03-06
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Albuminated Platelet Rich Fibrin: Venous blood will be collected in sterile tubes without anticoagulant and immediately centrifuged. The platelet-poor plasma (PPP) will be separated and

Sponsors

Samyukdha S K
Lead Sponsor
SRM Dental College
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1.Systemically healthy adults aged 25 to 65 years, of either gender 2.Periodontitis individuals with presence of bilateral periodontal pockets involving at least 2 interproximal sites in the posterior teeth maxilla or mandible suitable for split mouth allocation. 3.Presence of a minimum of 20 natural teeth overall, with at least 4 teeth in the quadrant of interest. 4.Patients who are willing to participate, provide written informed consent and comply with study procedures and scheduled follow up visits.

Exclusion criteria

Exclusion criteria: 1.History of periodontal therapy within the previous 6 months. 2.History of use of antibiotics, anti inflammatory drugs, corticosteroids, or immunosuppressive therapy within the last 3 months. 3.Sites with grade four furcation involvement , or grade two and three mobility. 4.Teeth with endodontic lesions or restorations or serving as abutments for FPD. 5.Individuals with known systemic diseases or conditions that may affect periodontal status or wound healing . 6.History of bleeding disorders or use of antiplatelet or anticoagulant therapy. 7.Smokers or users of any form of tobacco. 8.Pregnant or lactating women. 9.Individuals with poor oral hygiene compliance.

Design outcomes

Primary

MeasureTime frame
1. Periodontal Probing Depth 2. Clinical Attachment LevelTimepoint: Baseline,1 month and 3 months

Secondary

MeasureTime frame
NilTimepoint: Nil

Countries

India

Contacts

Public ContactAnupama Tadepalli

SRM Dental college

anupamamds@gmail.com9677065517

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026