Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery Health Condition 2: K053- Chronic periodontitis
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Intervention3: Nil: Nil
Intervention4: Nil: Nil
Sponsors
Dr Vasundhara Upreti
Eligibility
Inclusion criteria
Inclusion criteria: Group 1 (Systemically Healthy Individuals Without Periodontitis): o Age: 18-65 years of age o Pristine periodontal health o Clinical periodontal health (intact periodontium): Subjects with clinically healthy gingiva and free of gingival inflammation showing normal probing depths and height of bone with no or minimal probing on bleeding. o No systemic diseases (e.g., diabetes, cardiovascular diseases) o No smoking or tobacco use in the past 6 months o No medications that affect immune or inflammatory responses Group 2 (Patients with Stage II and Stage III Periodontitis): o Age: 18-65 years o Diagnosed with Stage II or Stage III periodontitis according to 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions o No history of systemic diseases o No smoking or tobacco use in the past 6 months o No medications that affect immune or inflammatory responses Group 3 (Patients with Stage II and Stage III Periodontitis and Coronary Artery Disease): o Age: 18-65 years o Diagnosed with Stage II or Stage III periodontitis (according to 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions) and coronary artery disease (confirmed by angiography or clinical diagnosis) o No history of other systemic diseases affecting immune response o No smoking or tobacco use in the past 6 months o No medications that affect immune or inflammatory responses
Exclusion criteria
Exclusion criteria: For all groups: o Pregnant or lactating women o Use of immunosuppressive drugs or systemic antibiotics in the past 3 months o Active oral infections other than periodontitis o Complicated with cardiomyopathy, congenital heart diseases, valvular diseases, or vasospastic angina o History of coronary artery bypass graft surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The study is anticipated to demonstrate significant differences in the peripheral blood expression levels of ANRIL, MALAT1, and H19 among systemically healthy individuals, patients with Stage II and III periodontitis, and patients with Stage II and III periodontitis associated with Coronary Artery Disease. A greater alteration in expression patterns may be observed in individuals with concomitant CAD, indicating a possible involvement of these lncRNAs in the common inflammatory mechanisms underlying both periodontal and cardiovascular conditions, and supporting their potential utility as systemic biomarkers.Timepoint: There is no different time points in this study. | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactDr Vasundhara Upreti
SRM Dental College, Ramapuram
Outcome results
None listed