A research to compare the intraoperative hemodynamics between dexmedetomidine with ketamine and dexmedetomidine with fentanyl when given in general anaesthesia

Usefulness of Ketamine versus Fentanyl as adjuvants with Dexmedetomidine infusion on perioperative hemodynamics and recovery profile - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105407

Enrollment

Registered

2026-03-05

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Inj Dexmedetomidine: Highly selective alpha 2 adrenergic receptor which has smooth and hemodynamically stable intraoperative course because of analgesic and anaesthetic sparing effect a

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 AND 2 18-60 yrs age Undergoing major abdominal surgery

Exclusion criteria

Exclusion criteria: ASA 3 nd 4 Heart block and arrhythmias Basal heart rate less than 60 Patients on anti hypertensives Known allergy to study drug Known chronic use of analgesics and sedatives Renal and hepatic dysfunction Psychiatric disorders Respiratory disorders and sleep apnea

Design outcomes

Primary

Measure	Time frame
To compare hemodynamic parameters and recovery parameters when using intraoperative Dexmedetomidine infusion with Ketamine versus Fentanyl as an adjuvantTimepoint: Intraoperative and 6 hrs postoperative 1st postoperative day	—

Secondary

Measure	Time frame
Compare anaesthetic sparing effect the need for post operative rescue analgesia adverse effects in post operative periodsTimepoint: Intraoperative & 6 hrs postoperative 1st postoperative day	—

Countries

India

Contacts

Public ContactDr Kavya S

Institute of Anaesthesiology Government Rajaji Hospital and Madurai Medical College

rajdeep181069@gmail.com9443183984

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026