Comparision of the efficacy of Dermaroller with Methotrexate 1 Percent gel and that of Clobetasol Propionate 0.05 Percent ointment in the treatment of Scalp Alopecia Areta

A Study Of Efficacy And Safety Of Microneedle Transdermal Delivery Of Methotrexate 1 Percent Gel Versus Microneedle Transdermal Delivery Of Clobetasol Propionate 0.05 Percent Ointment In The Treatment Of Scalp Alopecia Areata - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105339

Enrollment

Registered

2026-03-05

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L639- Alopecia areata, unspecified

Interventions

Intervention1: MICRONEEDLE TRANSDERMAL DELIVERY OF METHOTREXATE 1% GEL: for maximum 8 weeks at 2 weeks interval Intervention2: MICRONEEDLE TRANSDERMAL DELIVERY OF CLOBETASOL PROPIONATE 0.05% OINTMENT:

Eligibility

Inclusion criteria

Inclusion criteria: Patients of both genders of age more than 18 years with Localised Scalp Alopecia Areata

Exclusion criteria

Exclusion criteria: 1.Active systemic infection or localized scalp infection requiring systemic therapy. 2.Severely Immunocompromised. 3.Uncontrolled comorbidities like Diabetes Mellitus 4.Pregnancy. 5.Patients who have undergone treatment with other modalities in past 6 weeks

Design outcomes

Primary

Measure	Time frame
1.Measurement of efficacy of modalities on the basis of quartile grading scale 2.Lesional Area and Density Score 3.Severity TRichoscopy Index Alopecia Areata 4.Patient satisfaction using Likert Satisfaction ScaleTimepoint: at baseline every 2 weeks at end of 8 weeks	—

Secondary

Measure	Time frame
post procedural side effects of Methotrexate 1% gel and Clobetasol Propionate 0.05% Ointment with Microneedle Transdermal DeliveryTimepoint: at baseline every 2 weeks at end of 8 weeks	—

Countries

India

Contacts

Public ContactDr Callista Juneja

Sri Devaraj Urs Medical College, Tamaka, Kolar

callistajuneja@gmail.com09987754235

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026