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Comparing two techniques of anesthesia gas delivery to find out which technique uses less gas during major abdominal operations in adult patients

Comparison of Artificial intelligence guided target end tidal sevoflurane concentration and conventional sevoflurane use on consumption and uptake of sevoflurane in major abdominal surgery: A randomised clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/03/105325
Enrollment
60
Registered
2026-03-03
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Target End Tidal Sevoflurane: Sevoflurane shall be delivered according to artificial intelligence guided Target End Tidal Sevoflurane values generated by the workstation maintaining bis

Sponsors

Dr Shagun Bhatia Shah
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Posted for major abdominal surgery lasting more than 5h

Exclusion criteria

Exclusion criteria: Non consent Arrhythmias Hepatic dysfunction Renal dysfunction Malignant hyperpyrexia Raised intracranial pressure Seizures

Design outcomes

Primary

MeasureTime frame
Intraoperative consumption of sevofluraneTimepoint: 1 min after reversal of anesthesia—

Secondary

MeasureTime frame
Heart rate (HR) Timepoint: Baseline (1 min before induction of anesthesia), 5 min post intubation, The highest and lowest readings in each hour of Surgery ;Mean Arterial Pressure (MAP) Timepoint: Baseline (1 min before induction of anesthesia), 5 min post intubation, The highest and lowest readings in each hour of Surgery ;Pulse pressure variation (PPV) Timepoint: Baseline (1 min before induction of anesthesia), 5 min post intubation, The highest and lowest readings in each hour of Surgery;Bispectral index (BIS)Timepoint: Baseline (1 min before induction of anesthesia), 5 min post intubation, The highest and lowest readings in each hour of Surgery;Target end tidal sevoflurane Timepoint: Baseline (1 min before induction of anesthesia), 5 min post intubation, The highest and lowest readings in each hour of Surgery;Fraction of inspired sevofluraneTimepoint: Baseline (1 min before induction of anesthesia), 5 min post intubation, The highest and lowest readings in each hour of Surgery;End tidal sevofluraneTimepoint: Baseline (1 min before induction of anesthesia), 5 min post intubation, The highest and lowest readings in each hour of Surgery;Gastrointestinal function (PONV, time to first oral feed, bowel sound, flatus) Timepoint: 1h, 2h, 4h, 8h, 12h, 24h, 36h, and 48h post surgery—

Countries

India

Contacts

Public ContactDr Shagun Bhatia Shah

Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, Delhi

drshagun_2010@rediffmail.com09891769779

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026