Health Condition 1: B968- Other specified bacterial agents as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: Nil: Nil
Sponsors
Dr Aditya Parashar
Eligibility
Inclusion criteria
Inclusion criteria: Age: Adult patients (18 years). Diagnosis: Sepsis, defined according to Sepsis-3 criteria. Microbiological confirmation: Presence of carbapenem-resistant Gram-negative (CRGN) infections. Source of isolates: Confirmed from blood cultures or samples obtained from other sterile sites, including: Ascitic fluid Cerebrospinal fluid Urine Respiratory secretions
Exclusion criteria
Exclusion criteria: 1) Patients with solid organ transplants other than liver within six months 2) Patients with primary immunodeficiency disorders 3) Patients with HIV infection 4) Patients with who decline consent 5) Patients with CRGN colonization without active infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30-day all-cause mortality among sepsis patients infected with carbapenem-resistant gram-negative (CRGN) organisms, compared between those with and without liver cirrhosis.Timepoint: 30-days from culture positive date | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Identification & comparison of risk factors associated with CRGN infections in cirrhotic & non-cirrhotic patients (age, comorbidities, prior hospitalization, recent antibiotic exposure, nutritional status, & septic shock at presentation) . Timepoint: baseline on admission in icu;Detection & comparison of molecular mechanisms of carbapenem resistance (carbapenemase genes: KPC, NDM, VIM, OXA-48, IMP) between groupsTimepoint: During ICU stay;Evaluation of organ dysfunction related outcomes including 1.Development of acute kidney injury & requirement for renal replacement therapy 2.Need for invasive mechanical ventilation & duration of mechanical ventilation 3.Development of septic shock Timepoint: During ICU stay;Comparison of healthcare utilization outcomes 1.Duration of ICU stay 2.Total hospital length of stay Timepoint: During total Hospital stay;Comparison of antimicrobial susceptibility patterns of CRGN isolates between cirrhotic & non-cirrhotic patientsTimepoint: During total Hospital stay | — |
Countries
India
Contacts
Public ContactAditya Parashar
Amrita School of Medicine
Outcome results
None listed