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SIMEOX plus chest physiotherapy versus chest physiotherapy alone for improving sputum clearance in adults hospitalized with COPD exacerbation.

Effect of Simeox as a novel airway clearance device in the management of COPD patients with acute exacerbations: A randomised controlled trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/03/105263
Enrollment
43
Registered
2026-03-03
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J441- Chronic obstructive pulmonary disease with (acute) exacerbation

Interventions

Intervention1: CPT and Simeox: SIMEOX plus conventional chest physiotherapy for 14 days SIMEOX will be delivered 5 days/week on consecutive days. Control Intervention1: Conventional Chest Physiotherap

Sponsors

Centre for Physiotherapy and Rehabilitation Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adults more than or equal to 18 years old with AECOPD will be considered. Presence of not fully reversible airflow limitation, with an FEV1/ FVC less than 0.7 post bronchodilation measured by spirometry. COPD patients, GOLD stage II-IV Patients who are hospitalised for severe exacerbation of COPD experiencing worsening of dyspnoea, cough, and or sputum lasting up to 14 days, often accompanied by tachypnoea and tachycardia for duration less than 2 weeks. Significant Sputum production.

Exclusion criteria

Exclusion criteria: Patients that had under gone previous lung transplantation, required mechanical non-invasive ventilation for more than eight hours per day, had history of haemoptysis or pneumothorax in the last 12 months, were pregnant or breastfeeding. Severe cardiac comorbidities (recent heart attack, unstable angina, uncontrolled rhythm disorders, and unstable cardiac failure) or neuromuscular disorders. Patients who present with Asthma and Asthma-COPD overlap syndrome ACOS. Patients who present with other respiratory conditions such as bronchiectasis, cystic fibrosis and interstitial lung diseases.

Design outcomes

Primary

MeasureTime frame
sputum clearance dyspnea peak cough flowTimepoint: baseline and after 14 days intervention

Secondary

MeasureTime frame
pulmonary function arterial blood gases levels functional capacity health related quality of life anxiety and depressionTimepoint: baseline and after 14 days intervention

Countries

India

Contacts

Public ContactKritika Srivastava

Jamia Millia Islamia

aqsamuj786@gmail.com8130676908

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026