A study in liver transplant patients to compare different methods of giving fluids during surgery and their effect on recovery and complications.

Comparative Impact of Standardized Conventional Care, Pulse Pressure Variation-Guided, and Stroke Volume Variation- Guided Fluid Therapy on Total Intraoperative Fluid Administration and Postoperative Outcomes in Liver Transplantation: A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105251

Enrollment

Registered

2026-03-03

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K703- Alcoholic cirrhosis of liver Health Condition 2: K74- Fibrosis and cirrhosis of liver Health Condition 3: K769- Liver disease, unspecified

Interventions

Intervention1: Group PPV (PPV-Guided GDFT): Continuous PPV monitoring measured from an invasive arterial line PVV monitoring will be used exclusively in this group and will not be available or visible

if PPV remains more than or equal to 13 percent, repeat bolus. Use vasopressors if hypotension persists despite fluid optimisation. Intervention2: Group PPV (PPV-Guided GDFT): Continuous PPV monitori

if PPV remains more than or equal to 13 percent, repeat bolus. Use vasopressors if hypotension persists despite fluid optimisation. Control Intervention1: Group SCC (Standard Conventional Care): Inter

however, in cases of poor hemodynamic response, they may be temporarily unblinded and used as rescue tools

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients (18-65 years) of either sex of American Society of Anesthesiologists (ASA) physical Status III or IV scheduled to undergo elective living donor liver transplantation

Exclusion criteria

Exclusion criteria: Cardiac dysfunction such as valvular abnormalities, severe systolic dysfunction, Preexisting severe pulmonary disease, moderate-severe hepatopulmonary syndrome, Acute kidney injury, Acute liver failure, Re-transplantation, Patient refusal

Design outcomes

Primary

Measure	Time frame
To compare the total intraoperative fluid requirement among PPV-guided, SVV-guided, and standard care-guided fluid therapy in adult patients undergoing liver transplantation.Timepoint: at the end of surgery	—

Secondary

Measure	Time frame
Incidence & severity of post-reperfusion syndromeTimepoint: At the end of surgery;Vasopressor requirement (total dose, g per kg per min).Timepoint: at the end of surgery;Postoperative pulmonary function (e.g., Duration of postop mechanical ventilation, PaO2:FiO2 ratio, need for re-intubation, pulmonary complications such as fluid overload, ARDS or pneumonia)Timepoint: immediately postop, 3hr, 12hr, 6hr, 24hr, 48hr postoperatively;Post-op liver function (AST, ALT, INR, bilirubin).Timepoint: 24hr, 48hrs, 72hrs Postoperatively;Incidence of acute kidney injury (KDIGO criteria) & serum creatinine levels.Timepoint: at 1,2,3,4,5,6,7 days;30-day graft-related complicationTimepoint: ;Length of ICU and hospital stay (days)Timepoint:	—

Measure

Time frame

Incidence & severity of post-reperfusion syndromeTimepoint: At the end of surgery;Vasopressor requirement (total dose, g per kg per min).Timepoint: at the end of surgery;Postoperative pulmonary function (e.g., Duration of postop mechanical ventilation, PaO2:FiO2 ratio, need for re-intubation, pulmonary complications such as fluid overload, ARDS or pneumonia)Timepoint: immediately postop, 3hr, 12hr, 6hr, 24hr, 48hr postoperatively;Post-op liver function (AST, ALT, INR, bilirubin).Timepoint: 24hr, 48hrs, 72hrs Postoperatively;Incidence of acute kidney injury (KDIGO criteria) & serum creatinine levels.Timepoint: at 1,2,3,4,5,6,7 days;30-day graft-related complicationTimepoint: ;Length of ICU and hospital stay (days)Timepoint:

—

Countries

India

Contacts

Public ContactDr Udit Dhingra

Institute of Liver and Biliary Sciences

uddh1989@gmail.com8861987684

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026