Health Condition 1: M059- Rheumatoid arthritis with rheumatoid factor, unspecified
Conditions
Interventions
Intervention1: Structured Supervised Exercise Program: 8 weeks supervised program, 3 sessions per week, 60 minutes per session. Includes 10 min warm up, 20 min aerobic exercise on treadmill at 65 to 8
Sponsors
Sushma Singh Chauhan
Eligibility
Inclusion criteria
Inclusion criteria: 1. Confirmed Diagnosis of Rheumatoid Arthritis as per 2010 ACR EULAR classification criteria. 2. Disease duration of more than 6 months. 3. Stable DMARD therapy for at least 3 months prior to enrollment. 4. DAS28 score between 2.6 and 5.1 indicating low to moderate disease activity. 5. Baseline CRP greater than or equal to 3.0 mg per L or ESR greater than or equal to 20 mm per hr for men and 30 mm per hr for women. 6. Ability to walk independently without assistive devices. 7. Medical clearance for moderate intensity exercise.
Exclusion criteria
Exclusion criteria: 1. High disease activity with DAS28 greater than 5.1 2. Corticosteroid use greater than 10 mg per day. 3. Participation in any structured exercise program within the last 6 months. 4. Uncontrolled hypertension, recent myocardial infarction, or unstable angina. 5. Severe orthopedic limitations or joint surgery within last 6 months. 6. Other inflammatory conditions like SLE or psoriatic arthritis. 7. Active malignancy or cancer treatment within 5 years. 8. Pregnancy or breastfeeding. 9. Significant cognitive impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in serum C-reactive Protein (CRP) levels, Erythrocyte Sedimentation Rate (ESR) and Anti-Cyclic Citrullinated Peptide (Anti-CCP) AntibodiesTimepoint: Baseline and 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease Activity Score-28 (DAS28)Timepoint: Baseline, 4 weeks, and 8 weeks;Visual Analog Scale (VAS) for PainTimepoint: Baseline, 4 weeks, and 8 weeks;Health Assessment Questionnaire-Disability Index (HAQ-DI)Timepoint: Baseline, 4 weeks, and 8 weeks;Rheumatoid Arthritis Quality of Life (RAQOL)Timepoint: Baseline and 8 weeks;6-Minute Walk Test (6MWT)Timepoint: Baseline and 8 weeks | — |
Countries
India
Contacts
Public ContactDr Amita Aggarwal
Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation
Outcome results
None listed