Comparison of Two Nasal Medications (Dexmedetomidine and Clonidine) Given Before Anaesthesia to Control Heart Rate and Blood Pressure in Patients Undergoing Surgery.

A comparative study of intranasal dexmedetomidine and clonidine using a mucosal atomisation device on hemodynamic response t laryngoscopy during intubation - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105132

Enrollment

Registered

2026-03-02

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: dexmedetomidine: The intranasal dexmedetomidine (1mcg/kg) was administered evenly into both nostrils using a Mucosal Atomization Device (MAD), with a maximum volume of 0.5 mL per nostri

Eligibility

Inclusion criteria

Inclusion criteria: 18-60 years aged patients BMI 20-35 kg/m2 ASA I II Availability of written informed consent Hemodynamically stable patients with all routine investigations within normal limits.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
to compare the efficacy and safety of intranasal dexmedetomidine versus clonidine in controlling peri-intubation hemodynamic responses and providing adequate preoperative sedation.Timepoint: T0- baseline vitals before instillation of study drug T1- 10 min after instillation of study drug T2- 20 min after instillation of study drug T3- 30 min after instillation of study drug T4- 45 min after instillation of study drug T5 at the time of laryngoscopy and intubation T6- 1 min after intubation T7- 3 min after intubation T8- 5 min after intubation T9- 10 min after intubation	—

Measure

Time frame

to compare the efficacy and safety of intranasal dexmedetomidine versus clonidine in controlling peri-intubation hemodynamic responses and providing adequate preoperative sedation.Timepoint: T0- baseline vitals before instillation of study drug T1- 10 min after instillation of study drug T2- 20 min after instillation of study drug T3- 30 min after instillation of study drug T4- 45 min after instillation of study drug T5 at the time of laryngoscopy and intubation T6- 1 min after intubation T7- 3 min after intubation T8- 5 min after intubation T9- 10 min after intubation

—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Sonal Khatvkar

Dr. D. Y. PATIL MEDICAL COLLEGE, HOSPITAL AND RESEARCH CENTRE, PIMPRI, PUNE

ksonal0711@gmail.com9820434472

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026