Laparoscopic versus Open Surgical Repair for Perforated Peptic Ulcer in Adults: Perioperative Morbidity and Hospital Stay Comparison.

A Comparative Analysis of Open vs Laparoscopic repair of perforated peptic ulcer - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105110

Enrollment

Registered

2026-03-02

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K275- Chronic or unspecified peptic ulcer, site unspecified, with perforation Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: To compare the outcomes of laparoscopic versus open repair in patients with peptic perforation peritonitis.: 1.To compare operative time between the patient underwent laparoscopic vs op

Eligibility

Inclusion criteria

Inclusion criteria: 1.clinical and radiological evidence suggestive of perforated peptic ulcer with peritonitis. 2.Presentation within 72 hours of onset. 3.Hemodynamically stable patients fit for general anaesthesia.

Exclusion criteria

Exclusion criteria: 1.Patients of Perforated Peptic Ulcer Disease presenting after 72 hours of onset of symptoms. 2.Hemodynamically unstable patients 3.Previous upper abdominal surgeries 4.Suspected malignancy/perforation due to malignancy 5.Severe cardiopulmonary co-morbidities

Design outcomes

Primary

Measure	Time frame
To compare operative time between the patient underwent laparoscopic versus open repair in patients with peptic perforation peritonitis.Timepoint: Intra-operative (measured during surgery on Day 0).	—

Secondary

Measure	Time frame
1 Post operative pain score (VAS scale) 2 Incidence of post operative complications (wound infection, respiratory complications, intra abdominal abcess). 3 Length of hospital stay (days). 4 Mortality & morbidity rates (%). 5 Change in laboratory parameters from baseline Timepoint: 1 Post operative 24 hours (Day 1), 48 hours (Day 2), 72 hours (Day 3), & at 2 weeks follow up. 2 During hospital stay & at 2 weeks (Day 14), 6 weeks, & 12 weeks post surgery. 3 Assessed from day of admission to day of discharge (index hospitalization). 4 During hospital stay & within 30 days post surgery. 5 Pre operative (baseline, before surgery) post operative Day 3	—

Measure

Time frame

1 Post operative pain score (VAS scale) 2 Incidence of post operative complications (wound infection, respiratory complications, intra abdominal abcess). 3 Length of hospital stay (days). 4 Mortality & morbidity rates (%). 5 Change in laboratory parameters from baseline Timepoint: 1 Post operative 24 hours (Day 1), 48 hours (Day 2), 72 hours (Day 3), & at 2 weeks follow up. 2 During hospital stay & at 2 weeks (Day 14), 6 weeks, & 12 weeks post surgery. 3 Assessed from day of admission to day of discharge (index hospitalization). 4 During hospital stay & within 30 days post surgery. 5 Pre operative (baseline, before surgery) post operative Day 3

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Countries

India

Contacts

Public ContactMohammad Irfan

Department of surgery, Jawaharlal Nehru Medical College And Hospital, Aligarh Muslim University, Aligarh

drazrab@yahoo.in9756602489

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026