Health Condition 1: N00-N99- Diseases of the genitourinary system
Conditions
Interventions
Intervention1: Repeat dose of GnRh agonist trigger: A repeat-dose GnRH agonist trigger given in PCOS patients undergoing IVF cycles with GnRH antagonist protocol
Control Intervention1: Single dose of
Sponsors
Jhalak Jain
Eligibility
Inclusion criteria
Inclusion criteria: All women between the age 21-38 years, satisfying diagnostic criteria of PCOS according to ESHRE(2018)criteria which defines: Any 2 of 3 1.Irregular menstrual cycles and anovulation 2.Clinical or biochemical signs of hyperandrogenism 3.Polycystic ovarian morphology after excluding other disorders with similar clinical presentation
Exclusion criteria
Exclusion criteria: Other causes of anovulation/irregular menses-Hypothyroid, Hyperprolactinemia, Premature Ovarian Insufficiency Other causes of hyperandrogenemia like late onset Congenital Adrenal Hyperplasia, Cushing s Syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total oocytes retrieved and no. of mature oocytes retrievedTimepoint: 48 hours After ovum pickup | — |
Secondary
| Measure | Time frame |
|---|---|
| hormonal parameters (LH) at 12 hours post first trigger, oocyte maturity rate , number of top-quality embryos (day 3) & blastocysts (day 5), incidence of OHSS (if any) , clinical pregnancy rates following frozen embryo transferTimepoint: Till 4weeks post transfer | — |
Countries
India
Contacts
Public ContactJhalak Jain
Indira Gandhi Institute of medical sciences
Outcome results
None listed