A Study Comparing Two Types of Bone Grafts with Injectable PRF for Bone Regeneration in Lower Back Teeth

Comparative Clinical and Radiographic assessment of periodontal regeneration by employing combination of Biphasic Calcium Sulfate (CaSO4) bone graft + Injectable platelet rich fibrin (i-PRF) to Autogenous bone graft + i-PRF in management of Mandibular Grade II Furcation defects - Injectable platelet rich fibrin (i-PRF) Calcium Sulfate (CaSO4)

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/105099

Enrollment

Registered

2026-03-02

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K055- Other periodontal diseases

Interventions

Intervention1: Biphasic Calcium Sulfate bone graft (CaSO4) + i-PRF: Periodontal regeneration using Biphasic Calcium Sulfate (CaSO4) + i-PRF in mandibular grade II furcation defects Control Interventio

Eligibility

Inclusion criteria

Inclusion criteria: 1.Systemically healthy male or female patients aged between 20 years to 55 years who are willing to give their consent. 2.Patient with at least one mandibular molar tooth (mandibular 1st and 2 molars) with grade II furcation defect (Glickman classification 1958) 3.Patients having vertical probing pocket depth (PPD)greater than and equals to 5mm and greater than 3mm of horizontal probing depth but not entirely through and through furcation. 4.Patients willing to follow recommended plaque control and follow-up regimen and maintainable oral hygiene. 5.Patient s having full-mouth bleeding score (FMBS)less than 20% at surgery. 6.Patient s having greater than equals to 20 teeth present in oral cavity. 7.Patients diagnosed with Stage III periodontitis are included. 8.Patients having no history of any medication affecting periodontal healing.

Exclusion criteria

Exclusion criteria: 1.History of systemic diseases like diabetes mellitus, hypertension, chronic obstructive pulmonary diseases. 2.Patients with other types of furcation involvement of Grade I, III and IV. 3.Patients with severe cervical abrasion, root caries, vertical bone loss and tooth mobility grade I,II,III. 4.Patients having history of consumption of tobacco and smoking. 5.Sites with subgingival restorations and any type of prosthesis. 6.Pregnant and Lactating women.

Design outcomes

Primary

Measure	Time frame
1.Comparative clinical evaluation of periodontal regeneration with the use autogenous bone graft with i-PRF and Biphasic Calcium Sulfate (CaSO4) bone graft with i-PRF (Injectable platelet rich fibrin) in management of grade II furcation defects. 2.Comparative radiographic evaluation of bone fill at furcation site. Timepoint: Pre-operative, 3 months and post-operative 6 months	—

Secondary

Measure	Time frame
Comparative radiographic evaluation of bone fill at furcation site. Timepoint: Baseline and post-op 6 months	—

Countries

India

Contacts

Public ContactDr Madhu S Ratre

Government College of Dentistry, Indore

smadhu16feb@yahoo.co.in9406928976

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026