Evaluating the benefits of 1% melatonin usage in participants with periodontal bone loss so that there will be bone growth

Comparing regenerative potential of 1% Melatonin and Leukocyte-platelet rich fibrin (L-PRF) when used in treatment of periodontal defects a Split mouth Clinico-Radiographic study - NIL

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/03/0105781

Enrollment

Registered

2026-03-10

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: 1% melatonin granules: Access flap is elevated L- Prf loaded with 1% melatonin granules will be placed in intra bony defect after debridement of the site and is sutured along with pack

Eligibility

Inclusion criteria

Inclusion criteria: patient with no systemic disease ,probing pocket depth of 5 to 9 mm and horizontal defect depth of 3 to 5 mm

Exclusion criteria

Exclusion criteria: Patients with poor compliance. Patients with smoking habit. Pregnancy and lactation. Patients with any systemic disease Patients with Blood disorders Patients under any medication which alter the bone metabolism Patients with malocclusion and parafunctional habits. CBCT evaluation showing defect not suitable for grafting procedures

Design outcomes

Primary

Measure	Time frame
melatonin group show good bone fillTimepoint: melatonin group show good bone fill at 6 months	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public Contactkanike shravanth

Government dental collage and hospital Hyderabad

shkreddy9@yahoo.co.in9989989876

Outcome results