Comparing the quality of anesthesia administered by using Isoflurane (sedating agent) in patients undergoing surgery while being fully unconscious using GE Aisys CS 2 anesthesia machine by manually adjusting the anesthesia agent flow rate vs automated control by the anesthesia machine

Automated vs. Manual Control of Isoflurane Delivery for Quality and Recovery in Adult Surgical Patients Under General Anesthesia: An open-label randomised controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2026/03/0105118

Enrollment

Registered

2026-03-02

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: - Health Condition 3: O- Medical and Surgical Health Condition 4: O- Medical and Surgical

Interventions

Intervention1: Et control group: Usage of automated Et control mode of isoflurane delivery during general anesthesia with GE Aisys CS2 workstation Control Intervention1: Manual control group: Usage of

Eligibility

Inclusion criteria

Inclusion criteria: - ASA 1 to 3 patients - Patients undergoing surgery with general anesthesia - Intubated with PVC Endo tracheal tube

Exclusion criteria

Exclusion criteria: - Patient undergoing additional regional anesthesia technique - Patients not willing to participate in the study - Patients whose expected surgery duration is less than 3 hours - Pregnant/ Lactating mothers - Patient with psychiatric/ neurological disease/ taking any CNS drugs - Patients with any pre existing psychiatric conditions on medication.

Design outcomes

Primary

Measure	Time frame
Time taken for recovery from amesthesia - vocal response and tongue protrusionTimepoint: baseline value - only one value taken	—

Secondary

Measure	Time frame
To compare time between stopping of isoflurane and tracheal extubationTimepoint: To compare time between stopping of isoflurane and tracheal extubation;to estimate percent time BIS deviation from target +/- 10% between two study groupsTimepoint: through out surgery duration BIS monitoring;To estimate percent time Heart rate and mean arterial pressure deviation between two study groupsTimepoint: Throughout surgery HR and MAP monitoring at every 5 mins interval;To compare the total amount of isoflurane used throughout the surgery in two study groups.Timepoint: Value obtained from GE Aisys CS2 at the end of each surgery.;To comapre the total amount of fresh gases, oxygen, nitrous oxide used in the surgery in two study groupsTimepoint: Values obtained from GE Aisys CS2 anesthesia machine at the end of each surgery	—

Measure

Time frame

To compare time between stopping of isoflurane and tracheal extubationTimepoint: To compare time between stopping of isoflurane and tracheal extubation;to estimate percent time BIS deviation from target +/- 10% between two study groupsTimepoint: through out surgery duration BIS monitoring;To estimate percent time Heart rate and mean arterial pressure deviation between two study groupsTimepoint: Throughout surgery HR and MAP monitoring at every 5 mins interval;To compare the total amount of isoflurane used throughout the surgery in two study groups.Timepoint: Value obtained from GE Aisys CS2 at the end of each surgery.;To comapre the total amount of fresh gases, oxygen, nitrous oxide used in the surgery in two study groupsTimepoint: Values obtained from GE Aisys CS2 anesthesia machine at the end of each surgery

—

Countries

India

Contacts

Public ContactAfreed A

JIPMER - Puducherry

drsekarvmc@gmail.com8146555023

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026