Health Condition 1: L811- Chloasma
Conditions
Interventions
Intervention1: Microneedling With Topical Metformin: Topical metformin cream containing metformin hydrochloride fifteen grams in one hundred grams of cream base liquid paraffin twenty five grams beesw
Sponsors
Dr YASHASWINI G S
Eligibility
Inclusion criteria
Inclusion criteria: Female patients aged twenty to fifty years with clinically diagnosed facial melasma Fitzpatrick skin type three or four willing to give informed consent and comply with study protocol and not receiving any melasma treatment for at least three months prior to enrollment
Exclusion criteria
Exclusion criteria: Patients who are pregnant or breastfeeding Females with PCOD Smokers Active hormonal therapy Consumption of antioxidants in last Three months Use of isotretinoin in past six months Active inflammatory acne lesions Drugs causing photosensitivity and hyperpigmentation as epileptic drugs Antimilaria and tetracycline
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in modified Melasma Area And Severity Index score from baseline to the end of treatment in each group and comparison of mean percentage reduction in modified Melasma Area And Severity Index between microneedling with topical metformin and microneedling with topical glutathioneTimepoint: 4 weeks & 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in Global Photographic Assessment score & documentation of treatment related adverse effects & patient satisfaction in both groupsTimepoint: 4 weeks & 8 weeks | — |
Countries
India
Contacts
Public ContactDr Yashaswini G S
Sri Devaraj Urs Medical College
Outcome results
None listed