Comparison of Standard Versus Personalised hormone (progesterone) Support in Women Undergoing IVF and Its impact on Pregnancy Outcomes

Comparison of Standard versus Personalised Luteal Phase Support in patients undergoing frozen-thawed embryo transfer cycles: an open labelled randomised controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/105028

Enrollment

100

Registered

2026-02-27

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N97- Female infertility

Interventions

Intervention1: Personalised Luteal Phase Support: Serum progesterone will be first measured on the day of embryo transfer. Serum progesterone levels will be repeated serially on day 7 post embryo tran

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients undergoing frozen-thawed embryo transfer cycles 2. Age: 21 40 years old. 3. Availability of at least one good quality embryo (Day 5- 3BB and beyond, Day 3- 6 celled, grade B and beyond) 4. Willing to give consent

Exclusion criteria

Exclusion criteria: 1. Recurrent implantation failures (more than or equal to 3 failed transfers) 2. Diffuse adenomyosis 3. Multiple fibroids 4. Refusal to participate in study

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy rate: Presence of an intrauterine gestational sac with foetal cardiac activity, confirmed on transvaginal ultrasoundTimepoint: at 6 weeks of gestation	—

Secondary

Measure	Time frame
Biochemical pregnancy rate (UPT positive)Timepoint: 5 weeks gestation;Miscarriage rateTimepoint: 12 weeks gestation;ongoing pregnancy rateTimepoint: at 12 weeks of gestation;Serum progesterone levelsTimepoint: on the day of embryo transfer, day 7 post embryo transfer, day of pregnancy test (day 14 of embryo transfer), 6 weeks of gestation	—

Countries

India

Contacts

Public ContactDr Neena Malhotra

AIIMS Delhi

malhotraneenaaiims@gmail.com9891557707

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026