A study comparing inhaled dexmedetomidine and saline in controlling heart rate and blood pressure during breathing tube placement for laparoscopic gallbladder surgery.

Effect of inhaled dexmedetomidine on heart rate and blood pressure during anesthesia in patients undergoing laparoscopic gallbladder removal. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/104986

Enrollment

Registered

2026-02-27

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K80- Cholelithiasis

Interventions

Intervention1: DEXMEDETOMIDINE: PRE OPERATIVE NEBULIZATION VIA NASAL ROUTE WITH DEXMEDETOMIDINE WITH DOSE 1MICROGRAM PER KG MIXED WITH SALINE TO REACH A TOTAL VOLUME OF 5 ML WILL BE DONE Control Inter

Eligibility

Inclusion criteria

Inclusion criteria: AMERICAN SOCIETY OF ANAESTHESIOLOGISTS (ASA) PHYSICAL STATUS I-II,PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY REQUIRING ENDOTRACHEAL INTUBATION UNDER GENERAL ANAESTHESIA

Exclusion criteria

Exclusion criteria: 1. PATIENTS WITH A BODY MASS INDEX (BMI) MORE THAN 35 KG PER METER SQUARE 2. PATIENTS WITH INCREASED RISK OF REGURGITATION AND ASPIRATION OF GASTRIC CONTENT 3. PATIENTS WITH AIRWAY DIFFICULTY SCORE MORE THAN 8 4. PATIENTS WITH UPPER RESPIRATORY TRACT INFECTION 5. PATIENTS WITH HEPATIC OR RENAL INSUFFICIENCY 6. PATIENTS TAKING MEDICATIONS THAT AFFECT HEART RATE OR BLOOD PRESSURE 7. PREGNANT PATIENTS

Design outcomes

Primary

Measure	Time frame
TO ASSESS THE EFFECTS OF NEBULIZATION WITH DEXMEDETOMIDINE ON HEMODYNAMIC (HEART RATE, BLOOD PRESSURE) RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION AND DURING PNEUMOPERITONEUM Timepoint: HEMODYNAMIC PARAMETERS LIKE HEART RATE,BLOOD PRESSURE (SYSTOLIC AND DIASTOLIC) AT THE FOLLOWING TIME POINTS BEFORE NEBULISATION,AFTER NEBULISATION,BEFORE INDUCTION,IMMEDIATELY AFTER INDUCTION,1,3,5 MINUTES AFTER INTUBATION, 1,5,10 MINUTES AFTER CREATION OF PNEUMOPERITONEUM,AFTER DEFLATION,AT THE END OF SURGERY, AT 0 HOUR AFTER SURGERY WHEN PATIENT IS FULLY AWAKE AND AT 24 HRS POST SURGERY.	—

Measure

Time frame

TO ASSESS THE EFFECTS OF NEBULIZATION WITH DEXMEDETOMIDINE ON HEMODYNAMIC (HEART RATE, BLOOD PRESSURE) RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION AND DURING PNEUMOPERITONEUM Timepoint: HEMODYNAMIC PARAMETERS LIKE HEART RATE,BLOOD PRESSURE (SYSTOLIC AND DIASTOLIC) AT THE FOLLOWING TIME POINTS BEFORE NEBULISATION,AFTER NEBULISATION,BEFORE INDUCTION,IMMEDIATELY AFTER INDUCTION,1,3,5 MINUTES AFTER INTUBATION, 1,5,10 MINUTES AFTER CREATION OF PNEUMOPERITONEUM,AFTER DEFLATION,AT THE END OF SURGERY, AT 0 HOUR AFTER SURGERY WHEN PATIENT IS FULLY AWAKE AND AT 24 HRS POST SURGERY.

—

Secondary

Measure	Time frame
.TO STUDY SAFETY PROFILE OF NEBULISED DEXMEDETOMIDINE ON POSTOPERATIVE RECOVERY AND SORE THROATTimepoint: 0 HOURS AFTER SURGERY AND 24 HOURS POST SURGERY	—

Countries

India

Contacts

Public ContactLAKESH KUMAR ANAND

DEPARTMENT OF ANAESTHESIA, MM INSTITUTE OF MEDICAL SCIENCES AND RESEARCH,MULLANA,AMBALA

lkanand11@yahoo.com9646121522

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026