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Comparing the effect of two drugs in reducing morphine requirement in adult patients undergoing robotic operation in leg-up head-down position

Comparison of Target controlled infusions of dexmedetomidine versus propofol for robot-assisted surgery in steep Trendelenberg position: A randomised clinical study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/02/104923
Enrollment
60
Registered
2026-02-26
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Target controlled infusion of dexmedetomidine: During robot-assisted surgery in steep Trendelenberg position, Medcaptain infusion pump shall be used to administer dexmedetomidine after

Sponsors

Dr Shagun Bhatia Shah
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Weighing 45-80kg Posted for robot-assisted surgery in steep Trendelenberg position

Exclusion criteria

Exclusion criteria: Refusal to give consent Egg allergy Soy allergy Raised intracranial pressure Bradyarrhythmia Deranged LFT

Design outcomes

Primary

MeasureTime frame
Total opioid requirementTimepoint: 5min after surgery—

Secondary

MeasureTime frame
Total sevoflurane consumptionTimepoint: At the end of surgery;Numeric Rating Scale score for painTimepoint: 2h, 4h, 6h, 8h, 12h, and 24h post surgery;Heart rateTimepoint: Baseline Attaining effect site drug concentration Intubation 5 min post intubation Pneumoperitoneum After 1min, 1h, 2h, 3h in Steep Trendelenberg position 1 min after supination;Mean arterial pressureTimepoint: Baseline Attaining effect site drug concentration Intubation 5 min post intubation Pneumoperitoneum After 1min, 1h, 2h, 3h in Steep Trendelenberg position 1 min after supination;Perfusion indexTimepoint: Baseline Attaining effect site drug concentration Intubation 5 min post intubation Pneumoperitoneum After 1min, 1h, 2h, 3h in Steep Trendelenberg position 1 min after supination;Optic nerve sheath diameterTimepoint: Baseline Attaining effect site drug concentration Intubation 5 min post intubation Pneumoperitoneum After 1min, 1h, 2h, 3h in Steep Trendelenberg position 1 min after supination;Richmond agitation sedation scoreTimepoint: 2h, 4h, 6h, 8h, 12h, and 24h post surgery;Post operative nausea and vomitingTimepoint: 2h, 4h, 6h, 8h, 12h, and 24h post surgery;Length of surgical intensive care unit stayTimepoint: Shifting patient to ward orders;Total study drug consumptionTimepoint: At the end of surgery;ComplicationsTimepoint: Intraoperative period Postoperative period—

Countries

India

Contacts

Public ContactDr Shagun Bhatia Shah

Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, Delhi

drshagun_2010@rediffmail.com09891769779

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026