Different Methods for Instillation of Drugs which Enhance Lung Function in Preterm Babies

Videolaryngoscopy Versus Direct Laryngoscopy for Less Invasive Surfactant Administration in Preterm Infants with Respiratory Distress Syndrome: A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/104921

Enrollment

100

Registered

2026-02-26

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: P220- Respiratory distress syndrome of newborn

Interventions

Intervention1: Video laryngoscopy: Newborns requiring surfactant therapy through less invasive surfactant administration technique with the help of Video laryngoscopy Control Intervention1: Direct Lar

Eligibility

Inclusion criteria

Inclusion criteria: Neonates born between 25+0 weeks to 33+6 weeks, diagnosed with respiratory distress syndrome requiring surfactant therapy.

Exclusion criteria

Exclusion criteria: Neonates with congenital airway or heart anomalies, with severe birth asphyxia, with poor respiratory drive.

Design outcomes

Primary

Measure	Time frame
First attempt success rate of complete surfactant administration without repositioning using Video-laryngoscopy assisted LISA VS direct laryngoscopy assisted LISA in preterm newborn with respiratory distress syndrome requiring surfactant administration.Timepoint: First attempt success rate of complete surfactant administration without repositioning using Video-laryngoscopy assisted LISA VS direct laryngoscopy assisted LISA in preterm newborn with respiratory distress syndrome requiring surfactant administration.	—

Measure

Time frame

First attempt success rate of complete surfactant administration without repositioning using Video-laryngoscopy assisted LISA VS direct laryngoscopy assisted LISA in preterm newborn with respiratory distress syndrome requiring surfactant administration.Timepoint: First attempt success rate of complete surfactant administration without repositioning using Video-laryngoscopy assisted LISA VS direct laryngoscopy assisted LISA in preterm newborn with respiratory distress syndrome requiring surfactant administration.

—

Secondary

Measure	Time frame
Complications during procedure, time duration, need of mechanical ventilation and second dose of surfactantTimepoint: Within 7 days of surfactant administration	—

Countries

India

Contacts

Public ContactSumit Dagar

Graphic Era Institute of Medical Sciences

sumitdagar17@gmail.com8802740007

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026