Comparison of Oral Clonidine and Oral Metoprolol in improving surgical field by controlling bleeding and by improving visibility during Functional Endoscopic Sinus Surgery

Comparison of Efficacy of Oral Clonidine and Oral Metoprolol for Optimising Surgical field in Functional Endoscopic Sinus Surgery - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/104905

Enrollment

Registered

2026-02-26

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J010- Acute maxillary sinusitis

Interventions

Intervention1: Clonidine: Oral Tablet Clonidine 150 Microgram Given 1 Hour Prior Surgery Control Intervention1: METOPROLOL: Oral Tablet Metoprolol 25 Milligram Given 1 hour Prior Surgery

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA Grade 1 or 2 2. Patient undergoing Elective Endoscopic Sinus Surgery under General Anesthesia 3. Hemodynamic Stability SBP more than or equal to 100mmhg and HR more than or equal to 60 beats per minute

Exclusion criteria

Exclusion criteria: 1. Uncontrolled hypertension 2. Current use of beta blockers, calcium channel blockers or any other antihypertensives 3. Known hypersensitivity to clonidine or metoprolol 4. Severe renal, hepatic, respiratory disease , or uncontrolled diabetes mellitus 5. Pregnancy or Breastfeeding mother

Design outcomes

Primary

Measure	Time frame
To assess efficacy of oral clonidine versus oral metoprolol for optimizing surgical field in Functional endoscopic sinus surgeryTimepoint: Boezaart Average Category Scale score will be recorded every 30 minutes from start of surgery- 30,60,90,120 minutes until completion of surgery.	—

Secondary

Measure	Time frame
To assess the intraoperative hemodynamic parameters - Heart Rate, Systolic BP, Diastolic BP, Mean Arterial Pressure, recovery profile- extubation & recovery time, & the incidence of any other side effectTimepoint: Hemodynamic parameters recorded at baseline , post intubation & every 15 minutes intraoperatively until end of surgery.	—

Countries

India

Contacts

Public ContactDr Aparna Bagle

Dr. D.Y.Patil Medical , Hospital

draparnabagle@gmail.com9834430811

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026