Health Condition 1: N183- Chronic kidney disease, stage 3 (moderate) Health Condition 2: N182- Chronic kidney disease, stage 2 (mild) Health Condition 3: N184- Chronic kidney disease, stage 4 (severe) Health Condition 4: N181- Chronic kidney disease, stage 1 Health Condition 5: N185- Chronic kidney disease, stage 5 Health Condition 6: N179- Acute kidney failure, unspecified
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Intervention3: Nil: Nil
Intervention4: Nil: Nil
Sponsors
National Institute of Siddha
Eligibility
Inclusion criteria
Inclusion criteria: CASES: Participants will be eligible if they: Are male or female, aged 18 65 years Known case of renal disease with abnormal Renal findings. Participants will be included in the case group as per KDIGO (Kidney Disease Improving Global Outcomes) Guidelines. Renal disease marked by lowered eGFR Estimated glomerular filtration rate (eGFR) less than 90 millilitres per minute per1.73 square metre (CKD-EPI) Excretion of urinary proteins. Spot urine ACR greater than or equal to 30 milligrams per gram. (Albumin to creatinine ratio) Renal pathologies detected by imaging studies. CONTROLS: Age: 18-65 eGFR greater than or equal to 90 millilitres per minute per 1.73 square metre (normal function) Spot urine ACR less than 30 milligrams per gram No evidence of renal pathologies on imaging. Patients with any clinical conditions which does not act as a confounder in diagnosing Renal pathology.
Exclusion criteria
Exclusion criteria: CASES: Participants will be excluded if they: Belong to vulnerable group (pregnant and lactating women, children). Recent urinary tract instrumentation/surgery (less than 48h). Patients in emergency conditions/post- operative hospitalised patients. Known systemic illness affecting kidney function independently (e.g., advanced heart failure, severe liver disease, sepsis) where attribution to renal pathology is uncertain. CONTROLS: Vulnerable group (Pregnant and lactating women, children)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Specificity and Sensitivity of Naadi examination for the diagnosis of Renal pathology will be obtained at baseline.Timepoint: Baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive Predictive Value (PPV) & Negative Predictive Value (NPV) of Naadi examination for Renal pathology will be estimated at baseline. Positive Likelihood Ratio & Negative Likelihood Ratio of Naadi examination will be calculated at baseline. Pretest odds & Posttest odds of Renal pathology based on Naadi examination will be evaluated at baseline. Diagnostic performance of Naadi examination will be assessed using ROC curve analysis & Area Under the Curve (AUC) at baseline. Different Naadi patterns if observed in different stages of Renal pathology will be documented at baseline. Yakkai Ilakkanam for Renal pathology patients will be documented through validated questionnaires at baseline.Timepoint: Baseline | — |
Countries
India
Contacts
Public ContactProf Dr G J Christian
National institute of Siddha
Outcome results
None listed