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A study comparing two root canal cleaning methods to reduce pain between appointments in patients undergoing root canal treatment for adult back teeth.

EFFICACY OF CONTINUOUS SOFT CHELATION WITH ETIDRONIC ACID COMPARED TO SEQUENTIAL IRRIGATION ON INTERAPPOINTMENT PAIN FOLLOWING PRIMARY NON-SURGICAL ENDODONTIC TREATMENT OF PERMANENT MOLARS A RANDOMIZED CONTROLLED TRIAL - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/02/104778
Enrollment
140
Registered
2026-02-25
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Continuous Soft Chelation with Etidronic Acid: Patient receiving combined 18% HEBP and 5% NaOCl as irrigant (Continuous Soft Chelation- CSC) in primary non-surgical endodontic treatment

Sponsors

DR KEERTHANA SURENDRAN
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Adult patients with permanent molars indicated for nonsurgical endodontic treatment. 2 Molars diagnosed with symptomatic irreversible pulpitis with PAI score less than or equal to 2. 3 Participants willing to provide informed consent.

Exclusion criteria

Exclusion criteria: 1 Patients with uncontrolled systemic diseases 2 Patients who had taken analgesics within the last 8hrs of Treatment. 3 Non-restorable tooth and tooth with anatomical complexities, calcifications, weeping canals, sinus opening and periapical abscess 4 Teeth with periodontal pockets deeper than 4mm, endo-perio lesions and mobility. 5 Retreatment cases. 6 Allergy to the irrigants used

Design outcomes

Primary

MeasureTime frame
Interappointment pain assessed using Modified Visual Analogue Scale (VAS)Timepoint: baseline, 4, 12, 24 and 48 hours after the treatment.—

Secondary

MeasureTime frame
To assess the frequency of analgesic intake between the two groupsTimepoint: 4, 12, 24 and 48 hours after the treatment.;To assess the proportion of patients experiencing flare-ups after the procedure between the two groupsTimepoint: 4, 12, 24 and 48 hours after the treatment.—

Countries

India

Contacts

Public ContactDR REJULA F

GOVERNMENT DENTAL COLLEGE THIRUVANANTHAPURAM

rejula@hotmail.com9995227057

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026