A study to test whether applying hand compression with gloves can protect nerves in chemotherapy patients.

Hand compression in preventing Grade 2 or higher Chemotherapy-Induced Peripheral Neuropathy A single arm, phase 2 trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/104736

Enrollment

Registered

2026-02-25

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C509- Malignant neoplasm of breast of unspecified site Health Condition 2: C539- Malignant neoplasm of cervix uteri, unspecified Health Condition 3: C569- Malignant neoplasm of unspecifiedovary Health Condition 4: C349- Malignant neoplasm of unspecifiedpart of bronchus or lung Health Condition 5: C55- Malignant neoplasm of uterus, partunspecified

Interventions

Intervention1: Surgical gloves will be applied to patients hands: Patients gloves size will be identified. 2 surgical gloves one size smaller than patients actual glove size will be applied to patient

Eligibility

Inclusion criteria

Inclusion criteria: Patients diagnosed with cancer requiring paclitaxel administration ECOG performance status 0 2 No pre-existing peripheral neuropathy

Exclusion criteria

Exclusion criteria: Pre-existing neurologic disease Concurrent neurotoxic medication use Severe hepatic dysfunction that is AST,ALT 10 times upper limit of normal or Bilirubin 5 times upper limit of normal Pregnancy or lactation Abnormal baseline nerve conduction study report according to age

Design outcomes

Primary

Measure	Time frame
To evaluate the effectiveness of hand compression in preventing grade 2 or higher Chemotherapy induced peripheral neuropathy(CIPN) in patients receiving PaclitaxelTimepoint: Grading of Chemotherapy induced peripheral neuropathy will be done during each chemotherapy cycle using the National Cancer Institute Common Terminology Criteria for Adverse Events.It will be done every week for patients on 1 weekly regimen of chemotherapy and every 3 weeks for patients on 3 weekly regimen of chemotherapy and at 7 days after last chemotherapy cycle.	—

Measure

Time frame

To evaluate the effectiveness of hand compression in preventing grade 2 or higher Chemotherapy induced peripheral neuropathy(CIPN) in patients receiving PaclitaxelTimepoint: Grading of Chemotherapy induced peripheral neuropathy will be done during each chemotherapy cycle using the National Cancer Institute Common Terminology Criteria for Adverse Events.It will be done every week for patients on 1 weekly regimen of chemotherapy and every 3 weeks for patients on 3 weekly regimen of chemotherapy and at 7 days after last chemotherapy cycle.

—

Secondary

Measure	Time frame
To identify the incidence of grade 2 or higher chemotherapy induced peripheral neuropathy(CIPN) in patients receiving weekly vs 3 weekly paclitaxel undergoing hand compressionTimepoint: Grading of Chemotherapy induced peripheral neuropathy will be done during each chemotherapy cycle using the National Cancer Institute Common Terminology Criteria for Adverse Events.;To assess the severity of chemotherapy induced peripheral neuropathy(CIPN) using Nerve conduction study ( NCS)Timepoint: Nerve conduction study of all four limbs will be done prior to starting chemotherapy, post the mid cycle of chemotherapy & 7 days after completion of the last chemotherapy cycle.	—

Measure

Time frame

To identify the incidence of grade 2 or higher chemotherapy induced peripheral neuropathy(CIPN) in patients receiving weekly vs 3 weekly paclitaxel undergoing hand compressionTimepoint: Grading of Chemotherapy induced peripheral neuropathy will be done during each chemotherapy cycle using the National Cancer Institute Common Terminology Criteria for Adverse Events.;To assess the severity of chemotherapy induced peripheral neuropathy(CIPN) using Nerve conduction study ( NCS)Timepoint: Nerve conduction study of all four limbs will be done prior to starting chemotherapy, post the mid cycle of chemotherapy & 7 days after completion of the last chemotherapy cycle.

—

Countries

India

Contacts

Public ContactPuneeth KK

St. John s Medical College and Hospital

ganesha1705@gmail.com9972599314

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026