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A study to compare different medicines used for nerve block to reduce pain after knee replacement surgery

Comparative study of Ropivacaine alone versus Ropivacaine combined with Dexmedetomidine and Dexamethasone in ultrasound Guided Adductor canal Block for Postoperative Analgesia in unilateral Total Knee Arthroplasty - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/02/104716
Enrollment
110
Registered
2026-02-25
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: Nil: Nil Control Intervention1: Nil: Nil

Sponsors

Medanta The Medicity
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age: 18-75 years American Society of Anaesthesiologists (ASA) physical status I or II Scheduled for unilateral Total Knee Arthroplasty (TKA) Patients providing voluntary written informed consent.

Exclusion criteria

Exclusion criteria: Allergy to any study drugs (local anaesthetics, Dexamethasone, Dexmedetomidine). Chronic opioid use (defined as regular opioid use for more than 7 consecutive days within the last 3 months). Pregnancy or lactation. Pre-existing neurological or psychiatric illness that could interfere with pain assessment or cooperation. Inability to understand or cooperate with the study protocol or pain assessment scales. Contraindications to Adductor Canal Block (e.g., local infection at the injection site, coagulopathy). Patients undergoing bilateral TKA. Patients with pre-existing motor weakness or neuropathy of the lower limb. Patients with severe cardiac or respiratory comorbidities (ASA III and above).

Design outcomes

Primary

MeasureTime frame
To compare the duration of postoperative analgesia (time to first rescue analgesic requirement) between the subjects receiving 0.2% Ropivacaine alone and the subjects receiving 0.2% Ropivacaine with Dexmedetomidine (25 mcg) and Dexamethasone (6 mg) as adjuvants in Adductor Canal Block for TKA.Timepoint: Assessed 24 hour postoperatively—

Secondary

MeasureTime frame
1. To compare opioid consumption (total intravenous fentanyl equivalent), Visual Analog Scale (VAS) pain scores at various time points (0, 2, 4, 8, 16, 24 hours), & Sedation scores between the two groups. 2. To assess haemodynamic parameters (Heart Rate, Blood Pressure), & the occurrence of adverse effects (e.g., nausea, vomiting, dizziness, bradycardia, hypotension) in both groups. 3. To compare the early ambulation (by measuring number of steps walked on postoperative day 1 after 24 hour) between the two groups. Timepoint: Assessed 24 hour postoperatively—

Countries

India

Contacts

Public ContactNikita Rawat

Medanta the medicity

nikitarawat201297@gmail.com8979495845

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026