Comparing the Effectiveness of Diffrent Sugar Substitutes Combined with Milk in Reducing Cavity Causing Bacterial Levels in Children

Evaluation And Comparison Of Salivary Aquaporin-5 Level and Streptococcus Mutans Counts In Children Before And After Consumption Of Milk Sweetend With Xylitol,D-Allulose And Monk Fruit Sugar Substitutes-An In vivo study - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/02/104686

Enrollment

Registered

2026-02-24

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: xylitol sugar substitute: salivary Aquaporin 5 level and Streptococcus Mutans counts in children at baseline and 1 month after consumption of milk sweetened with commercially available

Eligibility

Inclusion criteria

Inclusion criteria: 1. Healthy Children aged 5-9 years of age. 2. Children with DMFT or dmft DC greater than or equal to 3, ICDAS 2 criteria with CODE 03 and 04. 3.Children who have not previously received sugar substitute therapy. 4.Children without any systemic disease. 5. Children who consumes milk at least three times per week. 6.No history of intolerance or adverse reaction to milk or sugar substitutes. 7.Written informed consent obtained from parents or guardians.

Exclusion criteria

Exclusion criteria: 1.Children with metabolic disorders, gastrointestinal Diseases and severe chronic illnesses. 2.Children with milk protein allergy, lactose intolerance or known hypersensitivity to sugar substitutes. 3.Children with Recent history of antibiotic usage. 4. Parents or children are unwilling to participate in the study.

Design outcomes

Primary

Measure	Time frame
Evaluation of Salivary Aquaporin 5 Levels and Streptococcus Mutans Counts In Children Before and After Consumption of Milk Sweetened with Xylitol, D Allulose and Monk Fruit Sugar Substitutes using Elisa and Mitis Salivarius Bacitracin Agar.Timepoint: Base line one month	—

Secondary

Measure	Time frame
Comparison of Salivary Aquaporin 5 Levels and Streptococcus Mutans Counts In Children Before and After Consumption of Milk Sweetened with Xylitol,D Allulose,Monk Fruit Sugar SubstitutesTimepoint: Base line one month	—

Countries

India

Contacts

Public ContactDr prathibha Gunasekaran

Rajarajeswari Dental College And Hospital

jaya.vrushabh@gmail.com9880038038

Outcome results