Health Condition 1: C340- Malignant neoplasm of main bronchus
Conditions
Interventions
Intervention1: Yoga + Pranayama Program (in addition to Standard Palliative Care): Patients will receive a structured 12-week yoga and pranayama program, delivered alongside their usual medical care.
Sponsors
Mahamana Pandit Madan Mohan Malaviya Cancer Centre MPMMCC
Eligibility
Inclusion criteria
Inclusion criteria: -Adult patients with histologically or cytologically confirmed carcinoma of the lung (NSCLC or SCLC). -Disease stage: Stage III or IV NSCLC, or extensive-stage SCLC. This includes patients with advanced loco-regional disease or metastatic disease. (Staging as per AJCC 8th edition). -Performance status: ECOG score 0, 1, or 2 (i.e., patients who are ambulatory and capable of all self-care; up to occasional assistance). -Life expectancy estimated to be at least 3 6 months in the judgment of the investigator (to allow completion of the 12-week intervention and assessment). -Experiencing a baseline impairment in global or domain-specific quality of life (not a strict numerical threshold, but patient should have some QoL concerns or symptom burden that could potentially be improved this is expected in most advanced lung cancer patients). -Able to understand one of the study languages (English or Hindi used for consent and questionnaires) and willing to complete QoL questionnaires (either self or, assisted by study nurse/coordinator). -Willing to provide written informed consent. -Willing to comply with study requirements, including attending regular yoga sessions and follow-up visits, and not enrolling in any conflicting interventional clinical trial during the study period. -Patients, who have received 1-2 cycles of chemotherapy, while awaiting NGS reports are also eligible to participate in the study.
Exclusion criteria
Exclusion criteria: -Presence of any medical contraindications to yoga/exercise: for example, unstable angina or uncontrolled congestive heart failure; severe orthopedic or neurologic conditions that preclude even mild physical activity; uncontrolled severe hypertension; or any condition that the treating physician deems would make yoga participation unsafe. -Symptomatic brain metastases or leptomeningeal disease that is uncontrolled. (Patients with CNS metastases can be included if they have received appropriate therapy and have stable symptoms, as judged by investigator, because they can then participate in yoga.) -Recent major surgery (within 4 weeks) or anticipated major surgery during the intervention period, which would impair ability to do yoga. -Concurrent participation in another intervention trial that could confound QoL outcomes (e.g., another exercise, drug, or psychosocial intervention trial). Participation in purely observational studies or registries is allowed. -Prior extensive experience with yoga or pranayama practice (defined as formal practice more than 2 times per week for more than 6 months in the past year). Rationale: we wish to avoid enrolling long-term yoga practitioners who may have less scope for further QoL improvement from the intervention, and to prevent dilution of effect. (Patients with minimal or past exposure to yoga can be included, but those who are current yoga instructors or very seasoned practitioners are excluded.) -Any other condition that, in the opinion of the investigators, makes the patient unsuitable for the study (for example, serious psychiatric disorders that interfere with participation, or inability to adhere to the protocol schedule).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| primary analysis will compare the mean change in global QoL between the intervention and control arms. An improvement of the global QoL score indicates better overall quality of lifeTimepoint: Total study duration 3 years. participant will participate in the trial for approximately 12 weeks expected recruitment period across centers is 24 months | — |
Secondary
| Measure | Time frame |
|---|---|
| EORTC QLQ-C30 Functional Scales.EORTC QLQ-C30 Symptom ScalesLung Cancer Specific Symptoms (EORTC QLQ-LC13 module.Psychological Distress Measures.Functional Exercise Capacity.Performance Status and Clinician-Assessed Outcomes.Survival Outcomes.Adverse Events related to the interventionTimepoint: Total study duration 3 years. participant will participate in the trial for approximately 12 weeks expected recruitment period across centers is 24 months | — |
Countries
India
Contacts
Public ContactDr Akhil Kapoor
Mahamana Pandit Madan Mohan Malaviya Cancer Centre (MPMMCC)
Outcome results
None listed