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A study to see whether repetitive transcranial magnetic stimulation can reduce headache frequency in people with chronic daily headache.

Efficacy and safety of repetitive transcranial magnetic stimulation in chronic daily headache A randomized controlled trial in a tertiary care centre - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/02/104656
Enrollment
40
Registered
2026-02-24
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G44- Other headache syndromes

Interventions

Intervention1: repetitive transcranial magnetic stimulation (rTMS) in active patients: Intermittent theta burst stimulation session will be delivered at two session per day 45 minutes apart for 5 days

Sponsors

Sri Guru Ram Rai Institute of Medical and Health Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with a diagnosis of Chronic Daily Headache as per the International Classification of Headache Disorders third edition ICHD-3 criteria. Patients aged between 18 to 59 years shall be included. Age of onset of headache shall be less than 50 years as per Diener et al. 2019. At least one headache episode per month with VAS greater than or equal to 50 mm. Patients giving written consent to participate in the protocol.

Exclusion criteria

Exclusion criteria: Medication overuse headache Exclusion of Secondary Headaches: Rule out secondary causes (e.g., trauma, infection, or intracranial pathology) either via history and clinical evaluation or imaging as needed (ICHD-3). Patient is uncooperative for the procedure Active substance use disorder (except caffeine and tobacco). Implanted metal or cerebral devices in head and neck History of unprovoked seizures, intracranial neoplasms or intracranial surgery, or history of severe head injury or cerebrovascular disease Patient having significant unstable medical condition like uncontrolled hypertension, complicated diabetes mellitus, etc Patient receiving ECT in last 6 months.

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the efficacy and safety of high-frequency repetitive transcranial magnetic stimulation (rTMS) versus sham stimulation in reducing the intensity, , days, frequency, and duration of headache episodes in patients with Chronic Daily Headache.Timepoint: day0, day7, day 21—

Secondary

MeasureTime frame
To assess and compare the impact of rTMS versus sham stimulation on functional disability and quality of life among patients with Chronic Daily Headache. To correlate the socio-demographic and clinical parameters with the outcome variables in rTMS group.Timepoint: day0, day7, day 21—

Countries

India

Contacts

Public ContactDr Abhishek Garg

Sri Guru Ram Rai Institute Of Medical and Health Sciences

Khattrisumit@gmail.com8218680546

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026