Health Condition 1: M488- Other specified spondylopathies Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Remifentanil: Remifentanil infusion at 0.1 g/kg/hr IV to maintain MAP 60 65 mmHg during surgery and for 6 hours postoperatively.
Intervention2: Tranexamic Acid: Tranexamic Acid loading
Sponsors
V. M. Vishaal
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adult patients aged 18 to 65 years 2. ASA Physical Status 1,2,3 3. Scheduled for elective posterior lumbar spine instrumental surgery 4. Willing to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Coagulopathy or bleeding disorders 2. Use of anticoagulant or antiplatelet drugs within 7 days 3. Allergy to Remifentanil or Tranexamic Acid 4. History of thromboembolic events in the past 6 months 5. Significant hepatic, renal, or cardiovascular disease 6. Patients on chronic opioid therapy 7. Pregnant or breastfeeding women 8. Unwilling to provide consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total perioperative blood loss (suction volume + gauze weight + postoperative drain output)Timepoint: At 24 hours after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reactive protein (CRP) levelsTimepoint: Preoperative (baseline), 24 hours postoperative, and 72 hours postoperative;Hemoglobin difference (preoperative vs 24 hours postoperative)Timepoint: Baseline and 24 hours postoperative;Surgical field visibility using Fromme Boezaart grading scaleTimepoint: Intraoperative period;Number and volume of blood transfusionsTimepoint: Intraoperative and first 24 hours postoperative;Adverse events (hypotension, bradycardia, thromboembolism)Timepoint: Intraoperative, 24 hours postoperative, and 72 hours postoperative | — |
Countries
India
Contacts
Public ContactDr G Mirunalini
SRM Medical College Hospital and Research Centre
Outcome results
None listed